|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[6cfm]] This PDB entry is obsolete and replaced by 6cfm |
| - | ==Crystal Structure of the Human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor==
| + | |
| - | <StructureSection load='6bw7' size='340' side='right' caption='[[6bw7]], [[Resolution|resolution]] 2.45Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[6bw7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW7 FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EA7:(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one'>EA7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
| + | |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw7 OCA], [http://pdbe.org/6bw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw7 ProSAT]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Disease ==
| + | |
| - | [[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Non-specific serine/threonine protein kinase]]
| + | |
| - | [[Category: Arruda, P]]
| + | |
| - | [[Category: Azevedo, A]]
| + | |
| - | [[Category: Counago, R M]]
| + | |
| - | [[Category: Edwards, A M]]
| + | |
| - | [[Category: Elkins, J M]]
| + | |
| - | [[Category: Ferreira, M]]
| + | |
| - | [[Category: Gama, F]]
| + | |
| - | [[Category: Guimaraes, C]]
| + | |
| - | [[Category: Mascarello, A]]
| + | |
| - | [[Category: Massirer, K B]]
| + | |
| - | [[Category: Reis, C V.dos]]
| + | |
| - | [[Category: Structural genomic]]
| + | |
| - | [[Category: Souza, G P.de]]
| + | |
| - | [[Category: Protein kinase domain]]
| + | |
| - | [[Category: Sgc]]
| + | |
| - | [[Category: Transferase]]
| + | |
| - | [[Category: Transferase-transferase inhibitor complex]]
| + | |
