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Phosphotriesterase

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<StructureSection load='' size='450' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>
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<StructureSection load='' size='350' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>
== Function ==
== Function ==
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*Phosphotriesterase complex with metal ion
*Phosphotriesterase complex with metal ion
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**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]] - BdPTE + Zn<br />
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**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]], [[5wcq]], [[6aml]] - BdPTE + Zn<br />
**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br />
**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br />
**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br />
**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br />
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**[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br />
**[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br />
**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />
**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />
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**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]] - SsPTE (mutant) + Co + Fe <br />
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**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]], [[5vri]], [[5vrk]], [[5vsa]], [[5w3u]], [[5w3z]] - SsPTE (mutant) + Co + Fe <br />
*Phosphotriesterase ternary complex with metal ion
*Phosphotriesterase ternary complex with metal ion

Revision as of 09:40, 20 August 2018

Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), 3cak

Drag the structure with the mouse to rotate

3D structures of phosphotriesterase

Updated on 20-August-2018

References

  1. ↑ Roodveldt C, Tawfik DS. Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state. Protein Eng Des Sel. 2005 Jan;18(1):51-8. PMID:15790580 doi:http://dx.doi.org/10.1093/protein/gzi005
  2. ↑ Bigley AN, Mabanglo MF, Harvey SP, Raushel FM. Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR. Biochemistry. 2015 Aug 25. PMID:26274608 doi:http://dx.doi.org/10.1021/acs.biochem.5b00629
  3. ↑ Kim J, Tsai PC, Chen SL, Himo F, Almo SC, Raushel FM. Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase. Biochemistry. 2008 Sep 9;47(36):9497-504. Epub 2008 Aug 15. PMID:18702530 doi:10.1021/bi800971v

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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