This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6bwn
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Mouse Protocadherin-15 EC6-7== | |
| - | + | <StructureSection load='6bwn' size='340' side='right' caption='[[6bwn]], [[Resolution|resolution]] 2.94Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bwn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwn OCA], [http://pdbe.org/6bwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bwn RCSB], [http://www.ebi.ac.uk/pdbsum/6bwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Klanseck, C F]] | ||
| + | [[Category: Neel, B L]] | ||
| + | [[Category: Sotomayor, M]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Calcium-binding protein]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Hearing]] | ||
| + | [[Category: Mechanotransduction]] | ||
Revision as of 08:17, 19 December 2018
Crystal Structure of Mouse Protocadherin-15 EC6-7
| |||||||||||
