1up0
From Proteopedia
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| - | [[Image:1up0. | + | [[Image:1up0.jpg|left|200px]]<br /><applet load="1up0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1up0" size=" | + | |
caption="1up0, resolution 1.75Å" /> | caption="1up0, resolution 1.75Å" /> | ||
'''STRUCTURE OF THE ENDOGLUCANASE CEL6 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CELLOBIOSE AT 1.75 ANGSTROM'''<br /> | '''STRUCTURE OF THE ENDOGLUCANASE CEL6 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CELLOBIOSE AT 1.75 ANGSTROM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UP0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with SO4, ACT and 1PG as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1UP0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=1PG:'>1PG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=1:1pg+Binding+Site+For+Chain+A'>1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UP0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: glycoside hydrolase]] | [[Category: glycoside hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:03:29 2008'' |
Revision as of 08:03, 3 February 2008
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STRUCTURE OF THE ENDOGLUCANASE CEL6 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CELLOBIOSE AT 1.75 ANGSTROM
Overview
The genomes of various Mycobacterium tuberculosis strains encode proteins, that do not appear to play a role in the growth or survival of the, bacterium in its mammalian host, including some implicated in plant cell, wall breakdown. Here we show that M. tuberculosis H37Rv does indeed, possess a functional cellulase. The x-ray crystal structure of this, enzyme, in ligand complex forms, from 1.9 to 1.1A resolution, reveals a, highly conserved substrate-binding cleft, which affords similar, and, unusual, distortion of the substrate at the catalytic center. The, endoglucanase activity, together with the existence of a putative, membrane-associated crystalline polysaccharide-binding protein, may, reflect the ancestral soil origin of the Mycobacterium or hint at a, previously unconsidered environmental niche.
About this Structure
1UP0 is a Single protein structure of sequence from Mycobacterium tuberculosis with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Mycobacterium tuberculosis strains possess functional cellulases., Varrot A, Leydier S, Pell G, Macdonald JM, Stick RV, Henrissat B, Gilbert HJ, Davies GJ, J Biol Chem. 2005 May 27;280(21):20181-4. Epub 2005 Apr 11. PMID:15824123
Page seeded by OCA on Sun Feb 3 10:03:29 2008
Categories: Mycobacterium tuberculosis | Single protein | Davies, G.J. | Gilbert, H.J. | Leydier, S. | Pell, G. | Varrot, A. | 1PG | ACT | SO4 | Family 6 | Glycoside hydrolase
