2dkb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2dkb.jpg|left|200px]]
[[Image:2dkb.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2dkb |SIZE=350|CAPTION= <scene name='initialview01'>2dkb</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_2dkb", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2,2-dialkylglycine_decarboxylase_(pyruvate) 2,2-dialkylglycine decarboxylase (pyruvate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.64 4.1.1.64] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2dkb| PDB=2dkb | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dkb OCA], [http://www.ebi.ac.uk/pdbsum/2dkb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dkb RCSB]</span>
+
-
}}
+
'''DIALKYLGLYCINE DECARBOXYLASE STRUCTURE: BIFUNCTIONAL ACTIVE SITE AND ALKALI METAL BINDING SITES'''
'''DIALKYLGLYCINE DECARBOXYLASE STRUCTURE: BIFUNCTIONAL ACTIVE SITE AND ALKALI METAL BINDING SITES'''
Line 23: Line 20:
==Reference==
==Reference==
Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites., Toney MD, Hohenester E, Cowan SW, Jansonius JN, Science. 1993 Aug 6;261(5122):756-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8342040 8342040]
Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites., Toney MD, Hohenester E, Cowan SW, Jansonius JN, Science. 1993 Aug 6;261(5122):756-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8342040 8342040]
-
[[Category: 2,2-dialkylglycine decarboxylase (pyruvate)]]
 
[[Category: Burkholderia cepacia]]
[[Category: Burkholderia cepacia]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 29: Line 25:
[[Category: Jansonius, J N.]]
[[Category: Jansonius, J N.]]
[[Category: Toney, M D.]]
[[Category: Toney, M D.]]
-
[[Category: lyase(decarboxylase)]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:36:11 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:35:43 2008''
+

Revision as of 21:36, 3 May 2008

Image:2dkb.jpg

Template:STRUCTURE 2dkb

DIALKYLGLYCINE DECARBOXYLASE STRUCTURE: BIFUNCTIONAL ACTIVE SITE AND ALKALI METAL BINDING SITES


Overview

The structure of the bifunctional, pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase was determined to 2.1-angstrom resolution. Model building suggests that a single cleavage site catalyzes both decarboxylation and transamination by maximizing stereoelectronic advantages and providing electrostatic and general base catalysis. The enzyme contains two binding sites for alkali metal ions. One is located near the active site and accounts for the dependence of activity on potassium ions. The other is located at the carboxyl terminus of an alpha helix. These sites help show how proteins can specifically bind alkali metals and how these ions can exert functional effects.

About this Structure

2DKB is a Single protein structure of sequence from Burkholderia cepacia. Full crystallographic information is available from OCA.

Reference

Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites., Toney MD, Hohenester E, Cowan SW, Jansonius JN, Science. 1993 Aug 6;261(5122):756-9. PMID:8342040 Page seeded by OCA on Sun May 4 00:36:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dkb"
Personal tools