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6ffr
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==DNA-RNA Hybrid Quadruplex with Flipped Tetrad== | |
| + | <StructureSection load='6ffr' size='340' side='right' caption='[[6ffr]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ffr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFR FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffr OCA], [http://pdbe.org/6ffr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffr RCSB], [http://www.ebi.ac.uk/pdbsum/6ffr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A DNA G-quadruplex adopting a (3+1)-hybrid structure was substituted at its 5'-tetrad by riboguanosine (rG) analogs. Incorporation of anti-favoring rG at appropriate syn-positions of the 5'-outer tetrad induced conformational rearrangements to yield a quadruplex featuring a 5'-tetrad with reversed polarity. A high-resolution structure of a disubstituted quadruplex variant as well as direct NMR experimental evidence reveals a non-conventional C-HO hydrogen bond in a medium groove between the 2'-OH of an rG residue adopting a C2'-endo sugar pucker and H8 of a 3'-neighboring anti-G residue. In contrast, a C3'-endo sugar conformation for another guanine ribonucleotide prevents formation of a corresponding hydrogen bond but relocates its 2'-OH substituent from the quadruplex narrow groove into a medium groove. Both the formation of favorable CHO hydrogen bridges and unfavorable interactions of the 2'-hydroxyl group in a narrow groove will promote RNA folding into a parallel topology featuring all-anti core residues and four grooves of medium size. | ||
| - | + | DNA-RNA Hybrid Quadruplexes Reveal Interactions that Favor RNA Parallel Topologies.,Haase L, Dickerhoff J, Weisz K Chemistry. 2018 Aug 7. doi: 10.1002/chem.201803367. PMID:30084512<ref>PMID:30084512</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6ffr" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dickerhoff, J]] | ||
| + | [[Category: Haase, L]] | ||
| + | [[Category: Weisz, K]] | ||
| + | [[Category: Dna-rna hybrid]] | ||
| + | [[Category: Quadruplex]] | ||
Revision as of 08:11, 26 September 2018
DNA-RNA Hybrid Quadruplex with Flipped Tetrad
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