5njv

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<StructureSection load='5njv' size='340' side='right' caption='[[5njv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5njv' size='340' side='right' caption='[[5njv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5njv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5njv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5njv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njv OCA], [http://pdbe.org/5njv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5njv RCSB], [http://www.ebi.ac.uk/pdbsum/5njv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5njv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5njv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njv OCA], [http://pdbe.org/5njv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5njv RCSB], [http://www.ebi.ac.uk/pdbsum/5njv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5njv ProSAT]</span></td></tr>
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== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A146CJG7_ZIKV A0A146CJG7_ZIKV]] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[SAAS:SAAS00892720]
[[http://www.uniprot.org/uniprot/A0A146CJG7_ZIKV A0A146CJG7_ZIKV]] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[SAAS:SAAS00892720]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zika virus, a flavivirus like Dengue and West Nile viruses, poses a significant risk as a pathogen in the category of emerging infectious diseases. Zika infections typically cause nonspecific, mild symptoms, but can also manifest as a neurological disorder like Guillain-Barre syndrome. Infection in pregnant women is linked to microcephaly in newborn infants. The methyltransferase domain of the non-structural protein 5 is responsible for two sequential methylations of the 5'-RNA cap. This is crucial for genome stability, efficient translation, and escape from the host immune response. Here we present the crystal structures of the Zika methyltransferase domain in complex with the methyl-donor SAM and its by-product SAH. The methyltransferase-SAH binary complex presents a new conformation of a "closed" or "obstructed" state that would restrict the binding of new RNA for capping. The combination and comparison of our new structures with recently published Zika methyltransferase structures provide a first glimpse into the structural mechanism of Zika virus mRNA capping.
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The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping.,Chatrin C, Talapatra SK, Canard B, Kozielski F Oncotarget. 2017 Dec 14;9(3):3160-3171. doi: 10.18632/oncotarget.23223., eCollection 2018 Jan 9. PMID:29423037<ref>PMID:29423037</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5njv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Zikv]]
[[Category: Chatrin, C]]
[[Category: Chatrin, C]]
[[Category: Kozielski, F]]
[[Category: Kozielski, F]]

Revision as of 06:26, 18 April 2018

Flavivirus NS5 domain

5njv, resolution 2.00Å

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