5xu0
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xu0 OCA], [http://pdbe.org/5xu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xu0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xu0 OCA], [http://pdbe.org/5xu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xu0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The spr0693-spr0694-spr0695 operon of Streptococcus pneumoniae encodes a putative ATP-binding cassette (ABC)-type efflux pump involved in the resistance of antibiotics and antimicrobial peptides. Here we report the crystal structures of Spr0694-0695 at 3.3 A and Spr0693 at 3.0 A resolution, revealing a MacAB-like efflux pump. The dimeric Spr0694-0695 adopts a non-canonical fold of ABC transporter, the transmembrane domain of which consists of eight tightly packed transmembrane helices with an insertion of extracellular domain between the first and second helices, whereas Spr0693 forms a nanotube channel docked onto the ABC transporter. Structural analyses combined with ATPase activity and antimicrobial susceptibility assays, enable us to propose a putative substrate-entrance tunnel with a lateral access controlled by a guard helix. Altogether, our findings provide structural insights and putative transport mechanism of a MacAB-like efflux pump in Gram-positive bacteria. | ||
| + | |||
| + | Structure of a MacAB-like efflux pump from Streptococcus pneumoniae.,Yang HB, Hou WT, Cheng MT, Jiang YL, Chen Y, Zhou CZ Nat Commun. 2018 Jan 15;9(1):196. doi: 10.1038/s41467-017-02741-4. PMID:29335499<ref>PMID:29335499</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5xu0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:09, 31 January 2018
Structure of the membrane fusion protein Spr0693 from Streptococcus pneumoniae R6
| |||||||||||
