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2dok

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[[Image:2dok.jpg|left|200px]]
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{{Structure
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|GENE= EST1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2dok| PDB=2dok | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dok OCA], [http://www.ebi.ac.uk/pdbsum/2dok PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dok RCSB]</span>
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'''Crystal structure of the PIN domain of human EST1A'''
'''Crystal structure of the PIN domain of human EST1A'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Takeshita, D.]]
[[Category: Takeshita, D.]]
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[[Category: telomerase-associated protein]]
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[[Category: Telomerase-associated protein]]
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[[Category: unknown function]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:53:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:37:31 2008''
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Revision as of 21:53, 3 May 2008

Image:2dok.jpg

Template:STRUCTURE 2dok

Crystal structure of the PIN domain of human EST1A


Overview

Saccharomyces cerevisiae Est1p is a telomerase-associated protein essential for telomere length homeostasis. hEST1A is one of the three human Est1p homologues and is considered to be involved not only in regulation of telomere elongation or capping but also in nonsense-mediated degradation of RNA. hEST1A is composed of two conserved regions, Est1p homology and PIN (PilT N-terminus) domains. The present study shows the crystal structure of the PIN domain at 1.8 A resolution. The overall structure is composed of an alpha/beta fold or a core structure similar to the counterpart of 5' nucleases and an extended structure absent from archaeal PIN-domain proteins and 5' nucleases. The structural properties of the PIN domain indicate its putative active center consisting of invariant acidic amino acid residues, which is geometrically similar to the active center of 5' nucleases and an archaeal PAE2754 PIN-domain protein associated with exonuclease activity.

About this Structure

2DOK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the PIN domain of human telomerase-associated protein EST1A., Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M, Proteins. 2007 Sep 1;68(4):980-9. PMID:17557331 Page seeded by OCA on Sun May 4 00:53:10 2008

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