4akv
From Proteopedia
(Difference between revisions)
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==Crystal structure of human sorting nexin 33 (SNX33)== | ==Crystal structure of human sorting nexin 33 (SNX33)== | ||
| - | <StructureSection load='4akv' size='340' side='right' caption='[[4akv]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='4akv' size='340' side='right'caption='[[4akv]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4akv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKV FirstGlance]. <br> | <table><tr><td colspan='2'>[[4akv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKV FirstGlance]. <br> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/SNX33_HUMAN SNX33_HUMAN]] Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.<ref>PMID:18353773</ref> <ref>PMID:18419754</ref> <ref>PMID:19487689</ref> <ref>PMID:20964629</ref> <ref>PMID:21048941</ref> <ref>PMID:22718350</ref> | [[http://www.uniprot.org/uniprot/SNX33_HUMAN SNX33_HUMAN]] Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.<ref>PMID:18353773</ref> <ref>PMID:18419754</ref> <ref>PMID:19487689</ref> <ref>PMID:20964629</ref> <ref>PMID:21048941</ref> <ref>PMID:22718350</ref> | ||
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| + | ==See Also== | ||
| + | *[[Sorting nexin|Sorting nexin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 12:47, 1 January 2020
Crystal structure of human sorting nexin 33 (SNX33)
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