4guo
From Proteopedia
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==structure of p73 DNA binding domain complex with 12 bp DNA== | ==structure of p73 DNA binding domain complex with 12 bp DNA== | ||
| - | <StructureSection load='4guo' size='340' side='right' caption='[[4guo]], [[Resolution|resolution]] 3.19Å' scene=''> | + | <StructureSection load='4guo' size='340' side='right'caption='[[4guo]], [[Resolution|resolution]] 3.19Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4guo]] is a 16 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4guo]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4guo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guo OCA], [https://pdbe.org/4guo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guo RCSB], [https://www.ebi.ac.uk/pdbsum/4guo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guo ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> |
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| + | ==See Also== | ||
| + | *[[P73|P73]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ethayathulla AS]] |
| - | [[Category: | + | [[Category: Viadiu H]] |
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Revision as of 07:18, 26 October 2022
structure of p73 DNA binding domain complex with 12 bp DNA
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