This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4hze

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Crystal structure of human Arginase-2 complexed with inhibitor 9==
==Crystal structure of human Arginase-2 complexed with inhibitor 9==
-
<StructureSection load='4hze' size='340' side='right' caption='[[4hze]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+
<StructureSection load='4hze' size='340' side='right'caption='[[4hze]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4hze]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4hze]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZE FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d3v|1d3v]], [[1pq3|1pq3]], [[4hww|4hww]], [[4hxq|4hxq]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hze OCA], [https://pdbe.org/4hze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hze RCSB], [https://www.ebi.ac.uk/pdbsum/4hze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hze ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hze OCA], [http://pdbe.org/4hze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hze RCSB], [http://www.ebi.ac.uk/pdbsum/4hze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hze ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
+
[https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 18:
</div>
</div>
<div class="pdbe-citations 4hze" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4hze" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Arginase 3D structures|Arginase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Arginase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
-
[[Category: Andreoli, M]]
+
[[Category: Andreoli M]]
-
[[Category: Beckett, P]]
+
[[Category: Beckett P]]
-
[[Category: Conway, B]]
+
[[Category: Conway B]]
-
[[Category: Cousido-Siah, A]]
+
[[Category: Cousido-Siah A]]
-
[[Category: Golebiowski, A]]
+
[[Category: Golebiowski A]]
-
[[Category: Ji, M]]
+
[[Category: Ji M]]
-
[[Category: Mahboubi, K]]
+
[[Category: Mahboubi K]]
-
[[Category: Mitschler, A]]
+
[[Category: Mitschler A]]
-
[[Category: Podjarny, A]]
+
[[Category: Podjarny A]]
-
[[Category: Ruiz, F X]]
+
[[Category: Ruiz FX]]
-
[[Category: Schroeter, H]]
+
[[Category: Schroeter H]]
-
[[Category: Sheeler, R]]
+
[[Category: Sheeler R]]
-
[[Category: Whitehouse, D L]]
+
[[Category: Van Zandt MC]]
-
[[Category: Zandt, M C.Van]]
+
[[Category: Whitehouse DL]]
-
[[Category: Zhang, M]]
+
[[Category: Zhang M]]
-
[[Category: Alpha/beta fold]]
+
-
[[Category: Arginine metabolism]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Manganese]]
+
-
[[Category: Metalloenzyme]]
+
-
[[Category: Mitochondrion]]
+

Revision as of 08:29, 9 November 2022

Crystal structure of human Arginase-2 complexed with inhibitor 9

PDB ID 4hze

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4hze"
Personal tools