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4i06

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==Crystal structure of human Arginase-2 complexed with inhibitor 14==
==Crystal structure of human Arginase-2 complexed with inhibitor 14==
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<StructureSection load='4i06' size='340' side='right' caption='[[4i06]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4i06' size='340' side='right'caption='[[4i06]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4i06]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I06 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4i06]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I06 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X8A:[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X8A</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X8A:[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X8A</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d3v|1d3v]], [[1pq3|1pq3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i06 OCA], [https://pdbe.org/4i06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i06 RCSB], [https://www.ebi.ac.uk/pdbsum/4i06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i06 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i06 OCA], [http://pdbe.org/4i06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i06 RCSB], [http://www.ebi.ac.uk/pdbsum/4i06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i06 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
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[https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4i06" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4i06" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Arginase 3D structures|Arginase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Andreoli, M]]
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[[Category: Andreoli M]]
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[[Category: Beckett, P]]
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[[Category: Beckett P]]
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[[Category: Conway, B]]
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[[Category: Conway B]]
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[[Category: Cousido-Siah, A]]
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[[Category: Cousido-Siah A]]
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[[Category: Golebiowski, A]]
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[[Category: Golebiowski A]]
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[[Category: Ji, M]]
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[[Category: Ji M]]
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[[Category: Mahboubi, K]]
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[[Category: Mahboubi K]]
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[[Category: Mitschler, A]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A]]
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[[Category: Podjarny A]]
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[[Category: Ruiz, F X]]
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[[Category: Ruiz FX]]
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[[Category: Schroeter, H]]
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[[Category: Schroeter H]]
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[[Category: Sheeler, R]]
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[[Category: Sheeler R]]
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[[Category: Whitehouse, D L]]
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[[Category: Van Zandt MC]]
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[[Category: Zandt, M C.Van]]
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[[Category: Whitehouse DL]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Alpha/beta fold]]
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[[Category: Arginine metabolism]]
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[[Category: Hydrolase]]
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[[Category: Manganese]]
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[[Category: Metalloenzyme]]
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[[Category: Mitochondrion]]
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Revision as of 08:30, 9 November 2022

Crystal structure of human Arginase-2 complexed with inhibitor 14

PDB ID 4i06

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