5fda

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==The high resolution structure of apo form dihydrofolate reductase from Yersinia pestis at 1.55 A==
==The high resolution structure of apo form dihydrofolate reductase from Yersinia pestis at 1.55 A==
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<StructureSection load='5fda' size='340' side='right' caption='[[5fda]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='5fda' size='340' side='right'caption='[[5fda]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fda]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis_co92 Yersinia pestis co92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FDA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fda]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FDA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.549&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, AK38_2080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214092 Yersinia pestis CO92])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fda OCA], [https://pdbe.org/5fda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fda RCSB], [https://www.ebi.ac.uk/pdbsum/5fda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fda ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fda OCA], [http://pdbe.org/5fda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fda RCSB], [http://www.ebi.ac.uk/pdbsum/5fda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fda ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A0B6NYF5_YERPE A0A0B6NYF5_YERPE]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]
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[https://www.uniprot.org/uniprot/A0A3N4BLI0_YERPE A0A3N4BLI0_YERPE] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194]
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Yersinia pestis co92]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Chang C]]
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[[Category: Chang, C]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A]]
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[[Category: Kim Y]]
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[[Category: Kim, Y]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Maltseva N]]
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[[Category: Maltseva, N]]
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[[Category: Mulligan R]]
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[[Category: Mulligan, R]]
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[[Category: Papazisi L]]
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[[Category: Papazisi, L]]
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[[Category: Csgid]]
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[[Category: Oxidoreductase]]
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[[Category: Yersinia pesti]]
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Current revision

The high resolution structure of apo form dihydrofolate reductase from Yersinia pestis at 1.55 A

PDB ID 5fda

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