2dtq

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[[Image:2dtq.jpg|left|200px]]
[[Image:2dtq.jpg|left|200px]]
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{{Structure
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|PDB= 2dtq |SIZE=350|CAPTION= <scene name='initialview01'>2dtq</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2dtq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2dtq| PDB=2dtq | SCENE= }}
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|RELATEDENTRY=[[1h3x|1H3X]], [[1e4k|1E4K]], [[1t83|1T83]], [[1l6x|1L6X]], [[1hzh|1HZH]], [[2dts|2DTS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dtq OCA], [http://www.ebi.ac.uk/pdbsum/2dtq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dtq RCSB]</span>
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'''Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1'''
'''Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1'''
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[[Category: Shitara, K.]]
[[Category: Shitara, K.]]
[[Category: Yamaguchi, Y.]]
[[Category: Yamaguchi, Y.]]
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[[Category: igg1]]
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[[Category: Igg1]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:21:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:39:19 2008''
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Revision as of 22:21, 3 May 2008

Image:2dtq.jpg

Template:STRUCTURE 2dtq

Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1


Overview

Removal of the fucose residue from the oligosaccharides attached to Asn297 of human immunoglobulin G1 (IgG1) results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to Fcgamma receptor IIIa. To provide structural insight into the mechanisms of affinity enhancement, we determined the crystal structure of the nonfucosylated Fc fragment and compared it with that of fucosylated Fc. The overall conformations of the fucosylated and nonfucosylated Fc fragments were similar except for hydration mode around Tyr296. Stable-isotope-assisted NMR analyses confirmed the similarity of the overall structures between fucosylated and nonfucosylated Fc fragments in solution. These data suggest that the glycoform-dependent ADCC enhancement is attributed to a subtle conformational alteration in a limited region of IgG1-Fc. Furthermore, the electron density maps revealed that the traces between Asp280 and Asn297 of our fucosylated and nonfucosylated Fc crystals were both different from that in previously reported isomorphous Fc crystals.

About this Structure

2DTQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1., Matsumiya S, Yamaguchi Y, Saito J, Nagano M, Sasakawa H, Otaki S, Satoh M, Shitara K, Kato K, J Mol Biol. 2007 May 4;368(3):767-79. Epub 2007 Feb 22. PMID:17368483 Page seeded by OCA on Sun May 4 01:21:58 2008

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