2duv

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[[Image:2duv.jpg|left|200px]]
[[Image:2duv.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2duv |SIZE=350|CAPTION= <scene name='initialview01'>2duv</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2duv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=371:2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE'>371</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2duv| PDB=2duv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2duv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2duv OCA], [http://www.ebi.ac.uk/pdbsum/2duv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2duv RCSB]</span>
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}}
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'''Structure of CDK2 with a 3-hydroxychromones'''
'''Structure of CDK2 with a 3-hydroxychromones'''
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[[Category: Lee, J.]]
[[Category: Lee, J.]]
[[Category: Park, T.]]
[[Category: Park, T.]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:25:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:39:51 2008''
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Revision as of 22:25, 3 May 2008

Image:2duv.jpg

Template:STRUCTURE 2duv

Structure of CDK2 with a 3-hydroxychromones


Overview

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

About this Structure

2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224 Page seeded by OCA on Sun May 4 01:25:22 2008

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OCA

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