2dw2

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[[Image:2dw2.jpg|left|200px]]
[[Image:2dw2.jpg|left|200px]]
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{{Structure
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|PDB= 2dw2 |SIZE=350|CAPTION= <scene name='initialview01'>2dw2</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_2dw2", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_2dw2| PDB=2dw2 | SCENE= }}
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|RELATEDENTRY=[[2dw0|2DW0]], [[2dw1|2DW1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dw2 OCA], [http://www.ebi.ac.uk/pdbsum/2dw2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dw2 RCSB]</span>
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'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)'''
'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)'''
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[[Category: Igarashi, T.]]
[[Category: Igarashi, T.]]
[[Category: Takeda, S.]]
[[Category: Takeda, S.]]
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[[Category: apoptotic toxin]]
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[[Category: Apoptotic toxin]]
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[[Category: metalloproteinase]]
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[[Category: Metalloproteinase]]
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[[Category: svmp]]
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[[Category: Svmp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:29:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:20 2008''
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Revision as of 22:29, 3 May 2008

Image:2dw2.jpg

Template:STRUCTURE 2dw2

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)


Overview

Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

About this Structure

2DW2 is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:17485084 Page seeded by OCA on Sun May 4 01:29:55 2008

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