2dwd

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[[Image:2dwd.gif|left|200px]]
[[Image:2dwd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2dwd |SIZE=350|CAPTION= <scene name='initialview01'>2dwd</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2dwd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=L2C:(2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL+LAURATE'>L2C</scene>, <scene name='pdbligand=TBA:TETRABUTYLAMMONIUM+ION'>TBA</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2dwd| PDB=2dwd | SCENE= }}
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|RELATEDENTRY=[[1k4c|1K4C]], [[2hvj|2HVJ]], [[2hvk|2HVK]], [[2dwe|2DWE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwd OCA], [http://www.ebi.ac.uk/pdbsum/2dwd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dwd RCSB]</span>
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}}
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'''crystal structure of KcsA-FAB-TBA complex in Tl+'''
'''crystal structure of KcsA-FAB-TBA complex in Tl+'''
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[[Category: Yohannan, S.]]
[[Category: Yohannan, S.]]
[[Category: Zhou, Y.]]
[[Category: Zhou, Y.]]
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[[Category: k+]]
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[[Category: K+]]
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[[Category: kcsa]]
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[[Category: Kcsa]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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[[Category: tetrabutylammonium]]
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[[Category: Tetrabutylammonium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:30:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:29 2008''
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Revision as of 22:31, 3 May 2008

Image:2dwd.gif

Template:STRUCTURE 2dwd

crystal structure of KcsA-FAB-TBA complex in Tl+


Overview

K(+) channels play essential roles in regulating membrane excitability of many diverse cell types by selectively conducting K(+) ions through their pores. Many diverse molecules can plug the pore and modulate the K(+) current. Quaternary ammonium (QA) ions are a class of pore blockers that have been used for decades by biophysicists to probe the pore, leading to important insights into the structure-function relation of K(+) channels. However, many key aspects of the QA-blocking mechanisms remain unclear to date, and understanding these questions requires high resolution structural information. Here, we address the question of whether intracellular QA blockade causes conformational changes of the K(+) channel selectivity filter. We have solved the structures of the KcsA K(+) channel in complex with tetrabutylammonium (TBA) and tetrabutylantimony (TBSb) under various ionic conditions. Our results demonstrate that binding of TBA or TBSb causes no significant change in the KcsA structure at high concentrations of permeant ions. We did observe the expected conformational change of the filter at low concentration of K(+), but this change appears to be independent of TBA or TBSb blockade.

About this Structure

2DWD is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Crystallographic study of the tetrabutylammonium block to the KcsA K+ channel., Yohannan S, Hu Y, Zhou Y, J Mol Biol. 2007 Feb 23;366(3):806-14. Epub 2006 Dec 2. PMID:17196615 Page seeded by OCA on Sun May 4 01:30:58 2008

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