5n86
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2== | |
| - | + | <StructureSection load='5n86' size='340' side='right' caption='[[5n86]], [[Resolution|resolution]] 1.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5n86]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N86 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N86 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n86 OCA], [http://pdbe.org/5n86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n86 RCSB], [http://www.ebi.ac.uk/pdbsum/5n86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n86 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STAB2_HUMAN STAB2_HUMAN]] Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.<ref>PMID:12077138</ref> <ref>PMID:12473645</ref> <ref>PMID:15208308</ref> <ref>PMID:15572036</ref> <ref>PMID:17145755</ref> <ref>PMID:17675564</ref> <ref>PMID:17962816</ref> <ref>PMID:18230608</ref> <ref>PMID:18434317</ref> <ref>PMID:18573870</ref> <ref>PMID:19359419</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dubin, G]] | ||
| + | [[Category: Grudnik, P]] | ||
| + | [[Category: Holak, T A]] | ||
| + | [[Category: Labuzek, B]] | ||
| + | [[Category: Twarda-Clapa, A]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Fas1 domain]] | ||
| + | [[Category: Hyaluronic acid receptor]] | ||
| + | [[Category: Stab2]] | ||
| + | [[Category: Stabilin-2]] | ||
Revision as of 05:23, 27 June 2018
Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2
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