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6erx

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Current revision (05:49, 4 April 2018) (edit) (undo)
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#REDIRECT [[6fxn]] This PDB entry is obsolete and replaced by 6fxn
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==Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab==
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<StructureSection load='6erx' size='340' side='right' caption='[[6erx]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6erx]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6erx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erx OCA], [http://pdbe.org/6erx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6erx RCSB], [http://www.ebi.ac.uk/pdbsum/6erx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6erx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Jiang, X]]
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[[Category: Lammens, A]]
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[[Category: Maskos, K]]
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[[Category: Schneider, P]]
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[[Category: Willen, L]]
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[[Category: Antibody]]
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[[Category: B cell]]
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[[Category: Baff]]
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[[Category: Cytokine]]
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[[Category: Immune system]]
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[[Category: Immunology]]
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[[Category: Protero]]
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Current revision

  1. REDIRECT 6fxn This PDB entry is obsolete and replaced by 6fxn

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