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3baf
From Proteopedia
(Difference between revisions)
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==Crystal structure of shikimate kinase from Mycobacterium tuberculosis in complex with AMP-PNP== | ==Crystal structure of shikimate kinase from Mycobacterium tuberculosis in complex with AMP-PNP== | ||
| - | <StructureSection load='3baf' size='340' side='right' caption='[[3baf]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='3baf' size='340' side='right'caption='[[3baf]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3baf]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3baf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BAF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SKM:(3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>SKM</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SKM:(3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>SKM</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroK ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3baf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3baf OCA], [https://pdbe.org/3baf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3baf RCSB], [https://www.ebi.ac.uk/pdbsum/3baf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3baf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Shikimate kinase]] | [[Category: Shikimate kinase]] | ||
[[Category: Azevedo, W F]] | [[Category: Azevedo, W F]] | ||
Revision as of 11:29, 5 January 2022
Crystal structure of shikimate kinase from Mycobacterium tuberculosis in complex with AMP-PNP
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Categories: Large Structures | Shikimate kinase | Azevedo, W F | Basso, L A | Dias, M V.B | Faim, L M | Ruggiero, N J | Santos, D S | Vasconcelos, I G | Amino-acid biosynthesis | Amp-pnp | Aromatic amino acid biosynthesis | Atp-binding | Cytoplasm | Magnesium | Metal-binding | Nucleotide-binding | Shikimate pathway | Transferase
