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3nxb

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Current revision (09:23, 6 September 2023) (edit) (undo)
 
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==Crystal Structure of the Bromodomain of human CECR2==
==Crystal Structure of the Bromodomain of human CECR2==
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<StructureSection load='3nxb' size='340' side='right' caption='[[3nxb]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='3nxb' size='340' side='right'caption='[[3nxb]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NXB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NXB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CECR2, KIAA1740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nxb OCA], [http://pdbe.org/3nxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nxb RCSB], [http://www.ebi.ac.uk/pdbsum/3nxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nxb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nxb OCA], [https://pdbe.org/3nxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nxb RCSB], [https://www.ebi.ac.uk/pdbsum/3nxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nxb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CECR2_HUMAN CECR2_HUMAN]] Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis.<ref>PMID:15640247</ref>
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[https://www.uniprot.org/uniprot/CECR2_HUMAN CECR2_HUMAN] Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis.<ref>PMID:15640247</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von]]
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[[Category: Bountra C]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Filippakopoulos, P]]
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[[Category: Filippakopoulos P]]
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[[Category: Keates, T]]
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[[Category: Keates T]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Muniz, J]]
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[[Category: Muniz J]]
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[[Category: Picaud, S]]
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[[Category: Picaud S]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Bromodomain]]
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[[Category: Cat eye syndrome chromosome region candidate 2]]
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[[Category: Cecr2]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of the Bromodomain of human CECR2

PDB ID 3nxb

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