1mpq

From Proteopedia

(Difference between revisions)

Revision as of 08:40, 2 December 2020

MALTOPORIN TREHALOSE COMPLEX

Structural highlights

1mpq is a 3 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	LAMB ("Bacillus coli" Migula 1895)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LAMB_ECOLI] Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic residues serves to guide and select the sugars for transport through the channel. Also acts as a receptor for several bacteriophages including lambda.[HAMAP-Rule:MF_01301]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Maltoporin (LamB) facilitates the diffusion of maltodextrins across the outer membrane of E. coli. The structural basis for the specificity of the channel is investigated by X-ray structure analysis of maltoporin in complex with the disaccharides sucrose, trehalose, and melibiose. The sucrose complex, determined to 2.4 A resolution, shows that the glucosyl moiety is partly inserted into the channel constriction, while the bulky fructosyl residue appears to be hindered to enter the constriction, thus interfering with its further translocation. One of the glucosyl moieties of trehalose is found in a similar position as the glucosyl moiety of sucrose, whereas melibiose appears disordered when bound to maltoporin. A comparison with the previously reported maltoporin-maltose complex sheds light on the basis for sugar discrimination, and explains the different permeation rates observed for the saccharides.

Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin.,Wang YF, Dutzler R, Rizkallah PJ, Rosenbusch JP, Schirmer T J Mol Biol. 1997 Sep 12;272(1):56-63. PMID:9299337^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wang YF, Dutzler R, Rizkallah PJ, Rosenbusch JP, Schirmer T. Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin. J Mol Biol. 1997 Sep 12;272(1):56-63. PMID:9299337 doi:http://dx.doi.org/10.1006/jmbi.1997.1224

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mpq"

@@ Line 1: / Line 1: @@
 ==MALTOPORIN TREHALOSE COMPLEX==
-<StructureSection load='1mpq' size='340' side='right' caption='[[1mpq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='1mpq' size='340' side='right'caption='[[1mpq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1mpq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MPQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1mpq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MPQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LAMB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpq OCA], [http://pdbe.org/1mpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mpq RCSB], [http://www.ebi.ac.uk/pdbsum/1mpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpq ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1mpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpq OCA], [http://pdbe.org/1mpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mpq RCSB], [http://www.ebi.ac.uk/pdbsum/1mpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpq ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 29: / Line 29: @@
 </div>
 <div class="pdbe-citations 1mpq" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Porin 3D structures|Porin 3D structures]]
 == References ==
 <references/>
@@ Line 34: / Line 37: @@
 </StructureSection>
 [[Category: Bacillus coli migula 1895]]
+[[Category: Large Structures]]
 [[Category: Dutzler, R]]
 [[Category: Schirmer, T]]

1mpq

From Proteopedia

Revision as of 08:40, 2 December 2020

MALTOPORIN TREHALOSE COMPLEX

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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