1lz8

From Proteopedia

(Difference between revisions)

Revision as of 12:37, 13 November 2019

LYSOZYME PHASED ON ANOMALOUS SIGNAL OF SULFURS AND CHLORINES

Structural highlights

1lz8 is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Activity:	Lysozyme, with EC number 3.2.1.17
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

A general method for solving the phase problem from native crystals of macromolecules has long eluded structural biology. For well diffracting crystals this goal can now be achieved, as is shown here, thanks to modern data collection techniques and new statistical phasing algorithms. Using solely a native crystal of tetragonal hen egg-white lysozyme, a protein of 14 kDa molecular mass, it was possible to detect the positions of the ten sulfur and seven chlorine atoms from their anomalous signal, and proceed from there to obtain an electron-density map of very high quality.

Can anomalous signal of sulfur become a tool for solving protein crystal structures?,Dauter Z, Dauter M, de La Fortelle E, Bricogne G, Sheldrick GM J Mol Biol. 1999 May 28;289(1):83-92. PMID:10339407^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
↑ Dauter Z, Dauter M, de La Fortelle E, Bricogne G, Sheldrick GM. Can anomalous signal of sulfur become a tool for solving protein crystal structures? J Mol Biol. 1999 May 28;289(1):83-92. PMID:10339407 doi:10.1006/jmbi.1999.2743

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lz8"

@@ Line 1: / Line 1: @@
 ==LYSOZYME PHASED ON ANOMALOUS SIGNAL OF SULFURS AND CHLORINES==
-<StructureSection load='1lz8' size='340' side='right' caption='[[1lz8]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
+<StructureSection load='1lz8' size='340' side='right'caption='[[1lz8]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1lz8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZ8 FirstGlance]. <br>
@@ Line 29: / Line 29: @@
 </div>
 <div class="pdbe-citations 1lz8" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 == References ==
 <references/>
@@ Line 34: / Line 37: @@
 </StructureSection>
 [[Category: Gallus gallus]]
+[[Category: Large Structures]]
 [[Category: Lysozyme]]
 [[Category: Bricogne, G]]

1lz8

From Proteopedia

Revision as of 12:37, 13 November 2019

LYSOZYME PHASED ON ANOMALOUS SIGNAL OF SULFURS AND CHLORINES

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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