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5z8f

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'''Unreleased structure'''
 
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The entry 5z8f is ON HOLD
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==Solution structure for the unique dimeric 4:2 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex==
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<StructureSection load='5z8f' size='340' side='right' caption='[[5z8f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5z8f]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9F0:4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline'>9F0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8f OCA], [http://pdbe.org/5z8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8f RCSB], [http://www.ebi.ac.uk/pdbsum/5z8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8f ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod) specifically binds the biological relevant hybrid-1 human telomeric G-quadruplex (Tel26), and strongly inhibits telomerase activity. Further investigations illustrate Pt-tripod induces the formation of monomeric and multimeric Pt-tripodTel26 complex structures in solution. We solve the 1:1 and the unique dimeric 4:2 Pt-tripod-Tel26 complex structures by NMR. The structures indicate preferential binding of Pt-tripod to the 5'-end of Tel26 at a low Pt-tripod/Tel26 ratio of 0-1.0. After adding more Pt-tripod, the Pt-tripod binds the 3'-end of Tel26, unexpectedly inducing a unique dimeric 4:2 structure interlocked by an A:A non-canonical pair at the 3'-end. Our structures provide a structural basis for understanding the dynamic binding of small molecules with G-quadruplex and DNA damage mechanisms, and insights into the recognition and assembly of higher-order G-quadruplexes.
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Authors: Liu, W.T., Zhong, Y.F., Liu, L.Y., Zeng, W.J., Wang, F.Y., Yang, D.Z., Mao, Z.W.
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Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding.,Liu W, Zhong YF, Liu LY, Shen CT, Zeng W, Wang F, Yang D, Mao ZW Nat Commun. 2018 Aug 29;9(1):3496. doi: 10.1038/s41467-018-05810-4. PMID:30158518<ref>PMID:30158518</ref>
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Description: Solution structure for the unique dimeric 4:2 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Yang, D.Z]]
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<div class="pdbe-citations 5z8f" style="background-color:#fffaf0;"></div>
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[[Category: Mao, Z.W]]
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== References ==
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[[Category: Zhong, Y.F]]
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<references/>
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[[Category: Liu, L.Y]]
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__TOC__
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[[Category: Zeng, W.J]]
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</StructureSection>
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[[Category: Liu, W.T]]
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[[Category: Liu, L Y]]
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[[Category: Wang, F.Y]]
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[[Category: Liu, W T]]
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[[Category: Mao, Z W]]
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[[Category: Wang, F Y]]
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[[Category: Yang, D Z]]
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[[Category: Zeng, W J]]
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[[Category: Zhong, Y F]]
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[[Category: Dimeric g-quadruplex]]
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[[Category: Dna]]
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[[Category: G-quadruplex complex]]
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[[Category: Human telomeric g-quadruplex]]

Revision as of 19:41, 19 September 2018

Solution structure for the unique dimeric 4:2 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex

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