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5z8n

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m (Protected "5z8n" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5z8n is ON HOLD
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==Crystal structure of Arabidopsis thaliana EBS C-terminal deletion construct in complex with an H3K4me2 peptide==
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<StructureSection load='5z8n' size='340' side='right' caption='[[5z8n]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5z8n]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8N FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8n OCA], [http://pdbe.org/5z8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8n RCSB], [http://www.ebi.ac.uk/pdbsum/5z8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/EBS_ARATH EBS_ARATH]] Chromatin remodeling factor that binds to methylated histone (e.g. H3K4me2/3) to prevent their acetylation (e.g. H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulating the transcription of target genes (PubMed:25281686). Negative regulator in developmental processes in a gibberellic acid- (GA-) dependent manner, such as germination, flowering induction, and flower organ specification, probably by modulating developmental gene expression (PubMed:11340178, PubMed:25281686). Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering (PubMed:25281686). Negatively regulates the expression of the floral integrator FT epigenetically, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation at FT locus (PubMed:25281686, PubMed:12837946).<ref>PMID:11340178</ref> <ref>PMID:12837946</ref> <ref>PMID:25281686</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Du, J]]
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[[Category: Yang, Z]]
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[[Category: Bah]]
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[[Category: Eb]]
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[[Category: Gene regulation]]
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[[Category: H3k4me2]]
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[[Category: Histone reader]]
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[[Category: Phd]]

Revision as of 07:10, 25 July 2018

Crystal structure of Arabidopsis thaliana EBS C-terminal deletion construct in complex with an H3K4me2 peptide

5z8n, resolution 3.10Å

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