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6c1a

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'''Unreleased structure'''
 
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The entry 6c1a is ON HOLD until Feb 14 2019
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==MBD2 in complex with methylated DNA==
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<StructureSection load='6c1a' size='340' side='right' caption='[[6c1a]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors: Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6c1a]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C1A FirstGlance]. <br>
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Description: MBD2 in complex with methylated DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c1a OCA], [http://pdbe.org/6c1a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c1a RCSB], [http://www.ebi.ac.uk/pdbsum/6c1a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c1a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN]] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
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[[Category: Liu, K]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Edwards, A.M]]
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[[Category: Structural genomic]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Tempel, W]]
[[Category: Xu, C]]
[[Category: Xu, C]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Dna binding]]
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[[Category: Liu, K]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Bountra, C]]
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[[Category: Dna methylation]]
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[[Category: Tempel, W]]
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[[Category: Sgc]]

Revision as of 06:34, 15 February 2018

MBD2 in complex with methylated DNA

6c1a, resolution 2.05Å

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