6c9d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of KA1-autoinhibited MARK1 kinase== | |
| - | + | <StructureSection load='6c9d' size='340' side='right' caption='[[6c9d]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c9d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C9D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c9d OCA], [http://pdbe.org/6c9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c9d RCSB], [http://www.ebi.ac.uk/pdbsum/6c9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c9d ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Emptage, R | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Emptage, R P]] | ||
[[Category: Marmorstein, R]] | [[Category: Marmorstein, R]] | ||
| + | [[Category: Autoinhibition]] | ||
| + | [[Category: Camkl]] | ||
| + | [[Category: Ka1 domain]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:42, 11 July 2018
Crystal structure of KA1-autoinhibited MARK1 kinase
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