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1o5p
From Proteopedia
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==Solution Structure of holo-Neocarzinostatin== | ==Solution Structure of holo-Neocarzinostatin== | ||
| - | <StructureSection load='1o5p' size='340' side='right' caption='[[1o5p]], [[NMR_Ensembles_of_Models | 60 NMR models]]' scene=''> | + | <StructureSection load='1o5p' size='340' side='right'caption='[[1o5p]], [[NMR_Ensembles_of_Models | 60 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1o5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5P FirstGlance]. <br> | <table><tr><td colspan='2'>[[1o5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5P FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5p OCA], [http://pdbe.org/1o5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5p RCSB], [http://www.ebi.ac.uk/pdbsum/1o5p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5p ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5p OCA], [http://pdbe.org/1o5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5p RCSB], [http://www.ebi.ac.uk/pdbsum/1o5p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | [[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces carzinostaticus]] | [[Category: Streptomyces carzinostaticus]] | ||
[[Category: Hasuda, K]] | [[Category: Hasuda, K]] | ||
Revision as of 18:46, 20 November 2019
Solution Structure of holo-Neocarzinostatin
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