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Sandbox Reserved 1430

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==Protein Structure==
==Protein Structure==
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The total number of amino acids in the protein is 548. The different <scene name='77/777750/Colored_secondary_structure/2'>secondary structures</scene> include alpha helices (seen in pink) and beta sheets (seen in gold). There are a mix of hydrophobic and hydrophilic amino acids that impact protein function. The color emitted by the enzyme is <scene name='77/777750/Critical_amino_acid/2'>green</scene> in the wild type and <scene name='77/777750/Mutant_luciferase/1'>red</scene> in the mutant due to changes in protein folding.
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==Function==
==Function==
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Luciferase catabolizes luciferin, which forms a bio-luminescent product. This reaction consumes ATP and oxygen. Luciferase is an oxidoreducase
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==Significance==
==Significance==
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<scene name='77/777750/Colored_secondary_structure/2'>TextToBeDisplayed</scene>
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Luciferase is an enzyme commonly used in imaging in the biotechnology industry. A cell line of interest can be genetically engineered to express this enzyme by using a viral vector. Once the model organism has been inoculated with the cell line of interest, luciferin can be administer to track localization and growth. If that cell line of interest was a cancer cell line, then a biopharmaceutical treatment could be tested for reduction in tumor size and metastasis.
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<scene name='77/777750/Critical_amino_acid/2'>Text To Be Displayed</scene>
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<scene name='77/777750/Mutant_luciferase/1'>Text To Be Displayed</scene>
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== Function ==
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== Disease ==
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== Relevance ==
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== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
 
== References ==
== References ==
<references/>
<references/>
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https://www.rcsb.org/structure/2D1S
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http://pdb101.rcsb.org/motm/78

Revision as of 01:29, 11 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Luciferase

Protein structure of luciferase

Drag the structure with the mouse to rotate
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