This is a page on COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT.
Organism of Origin
This protein comes form the African Clawed Frog (Xenopus Laevis)
Structure
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome.
There are a total of 418 which make up different histone structures on the inside.
The is found on the outside. The DNA chains are 146 nucleotides long.
There are also 6 in this protein.
Fun fact: The DNA in this protein is palindromic.
Function
This protein is involved in DNA binding, transcription, and initiation.
Significance
This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome.
References
Discussion 1-3.docx
http://www.ebi.ac.uk/pdbe/entry/pdb/1aoi
https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310
