This is a page on COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT.
Organism of Origin
This protein comes form the African Clawed Frog (
Xenopus Laevis)
Structure
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome.
There are a total of 418 which make up different histone structures on the inside.
The is found on the outside. The DNA chains are 146 nucleotides long.
There are also 6 in this protein.
Fun fact: The DNA in this protein is palindromic.
Function
This protein is involved in DNA binding, transcription, and initiation.
Significance
This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome.
References
Discussion 1-3.docx
http://www.ebi.ac.uk/pdbe/entry/pdb/1aoi
https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310