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6ccf

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m (Protected "6ccf" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ccf is ON HOLD
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==Crystal Structure of the Human CAMKK1A in complex with Hesperadin==
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<StructureSection load='6ccf' size='340' side='right' caption='[[6ccf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Santiago, A.S., Counago, R.M., dos Reis, C.V., Ramos, P.Z., Drewry, D., Elkins, J.M., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ccf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CCF FirstGlance]. <br>
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Description: Crystal Structure of the Human CAMKK1A in complex with Hesperadin
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H1N:N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE'>H1N</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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[[Category: Elkins, J.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccf OCA], [http://pdbe.org/6ccf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ccf RCSB], [http://www.ebi.ac.uk/pdbsum/6ccf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccf ProSAT]</span></td></tr>
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[[Category: Massirer, K.B]]
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</table>
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[[Category: Counago, R.M]]
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== Function ==
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[[Category: Dos Reis, C.V]]
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[[http://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN]] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Arruda, P]]
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[[Category: Counago, R M]]
[[Category: Drewry, D]]
[[Category: Drewry, D]]
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[[Category: Edwards, A.M]]
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[[Category: Edwards, A M]]
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[[Category: Arruda, P]]
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[[Category: Elkins, J M]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Massirer, K B]]
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[[Category: Santiago, A.S]]
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[[Category: Ramos, P Z]]
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[[Category: Ramos, P.Z]]
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[[Category: Reis, C V.dos]]
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[[Category: Structural genomic]]
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[[Category: Santiago, A S]]
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[[Category: Silva, P N.B]]
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[[Category: Protein kinase domain]]
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[[Category: Psi-biology]]
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[[Category: Sgc]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 05:08, 8 March 2018

Crystal Structure of the Human CAMKK1A in complex with Hesperadin

6ccf, resolution 2.10Å

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