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5v7a

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Current revision (13:43, 4 October 2023) (edit) (undo)
 
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==E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-((2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)acetic acid==
==E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-((2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)acetic acid==
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<StructureSection load='5v7a' size='340' side='right' caption='[[5v7a]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='5v7a' size='340' side='right'caption='[[5v7a]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5v7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecol6 Ecol6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V7A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5v7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V7A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Y7:[(2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]acetic+acid'>8Y7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u0v|5u0v]], [[5u0y|5u0y]], [[5u0x|5u0x]], [[5u0w|5u0w]], [[5u10|5u10]], [[5u13|5u13]], [[5u12|5u12]], [[5u11|5u11]], [[5u0z|5u0z]], [[5u14|5u14]], [[5v79|5v79]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Y7:[(2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]acetic+acid'>8Y7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folP, c3933 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7a OCA], [https://pdbe.org/5v7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v7a RCSB], [https://www.ebi.ac.uk/pdbsum/5v7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7a ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7a OCA], [http://pdbe.org/5v7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v7a RCSB], [http://www.ebi.ac.uk/pdbsum/5v7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7a ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHPS_ECOL6 DHPS_ECOL6]] Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.[UniProtKB:P0AC13]
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[https://www.uniprot.org/uniprot/DHPS_ECOLI DHPS_ECOLI] DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.<ref>PMID:368012</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5v7a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5v7a" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydropteroate synthase]]
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[[Category: Escherichia coli CFT073]]
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[[Category: Ecol6]]
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[[Category: Large Structures]]
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[[Category: Dennis, M L]]
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[[Category: Dennis ML]]
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[[Category: Peat, T S]]
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[[Category: Peat TS]]
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[[Category: Swarbrick, J D]]
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[[Category: Swarbrick JD]]
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[[Category: Complex]]
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[[Category: Dhp]]
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[[Category: E. coli]]
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[[Category: Pterin site]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-((2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)acetic acid

PDB ID 5v7a

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