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6be1
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6be1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6be1 OCA], [http://pdbe.org/6be1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6be1 RCSB], [http://www.ebi.ac.uk/pdbsum/6be1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6be1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6be1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6be1 OCA], [http://pdbe.org/6be1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6be1 RCSB], [http://www.ebi.ac.uk/pdbsum/6be1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6be1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Serotonin receptors (5-HT3AR) directly regulate gut movement, and drugs that inhibit 5-HT3AR function are used to control emetic reflexes associated with gastrointestinal pathologies and cancer therapies. The 5-HT3AR function involves a finely tuned orchestration of three domain movements that include the ligand-binding domain, the pore domain, and the intracellular domain. Here, we present the structure from the full-length 5-HT3AR channel in the apo-state determined by single-particle cryo-electron microscopy at a nominal resolution of 4.3 A. In this conformation, the ligand-binding domain adopts a conformation reminiscent of the unliganded state with the pore domain captured in a closed conformation. In comparison to the 5-HT3AR crystal structure, the full-length channel in the apo-conformation adopts a more expanded conformation of all the three domains with a characteristic twist that is implicated in gating. | ||
| + | |||
| + | Cryo-EM structure of 5-HT3A receptor in its resting conformation.,Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S Nat Commun. 2018 Feb 6;9(1):514. doi: 10.1038/s41467-018-02997-4. PMID:29410406<ref>PMID:29410406</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6be1" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:15, 28 February 2018
Cryo-EM structure of serotonin receptor
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