2elb

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elb OCA], [http://www.ebi.ac.uk/pdbsum/2elb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2elb RCSB]</span>
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'''Crystal Structure of the BAR-PH domain of human APPL1'''
'''Crystal Structure of the BAR-PH domain of human APPL1'''
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[[Category: Mao, X.]]
[[Category: Mao, X.]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: appl]]
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[[Category: Appl]]
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[[Category: bar domain]]
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[[Category: Bar domain]]
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[[Category: ph domain]]
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[[Category: Ph domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:43:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:50:45 2008''
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Revision as of 23:43, 3 May 2008

Image:2elb.gif

Template:STRUCTURE 2elb

Crystal Structure of the BAR-PH domain of human APPL1


Overview

APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.

About this Structure

2ELB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of the BAR-PH and PTB domains of human APPL1., Li J, Mao X, Dong LQ, Liu F, Tong L, Structure. 2007 May;15(5):525-33. PMID:17502098 Page seeded by OCA on Sun May 4 02:43:11 2008

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