Serpin
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='2xn6' size=' | + | <StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'> |
== Function == | == Function == | ||
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | '''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | ||
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**[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br /> | **[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br /> | ||
**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br /> | **[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br /> | ||
| + | **[[5om2]], [[5om3]], [[5om5]], [[5om6]], [[5om7]], [[5om8]], [[6ftp]] – hSer-A3 (mutant) + antibiotic<br /> | ||
**[[1yxa]] – mSer-A3N - mouse<br /> | **[[1yxa]] – mSer-A3N - mouse<br /> | ||
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*Serpin A6 see [[Corticosteroid-binding globulin]] | *Serpin A6 see [[Corticosteroid-binding globulin]] | ||
| - | *Serpin A7 | + | *Serpin A7 or thyroxine-binding globulin |
**[[2riv]] – hSer-A7<br /> | **[[2riv]] – hSer-A7<br /> | ||
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**[[4yia]] - hSer-A7 + indomethacin<br /> | **[[4yia]] - hSer-A7 + indomethacin<br /> | ||
| - | *Serpin A8 | + | *Serpin A8 or angiotensin-II |
**[[2jp8]] – hSer-A8 – NMR<br /> | **[[2jp8]] – hSer-A8 – NMR<br /> | ||
| - | **[[2wxw]], [[ | + | **[[2wxw]], [[5m3x]], [[5m3y]] – hSer-A8<br /> |
**[[2x0b]] – hSer-A8 + renin<br /> | **[[2x0b]] – hSer-A8 + renin<br /> | ||
| - | **[[2wxx]], [[2wxy]], [[2wy0]] – | + | **[[5e2q]] – hSer-A8 + DPP<br /> |
| + | **[[4fys]] – hSer-A8 + CD13<br /> | ||
| + | **[[2wxx]], [[2wxy]], [[2wy0]] – mSer-A8 – mouse<br /> | ||
**[[2wxz]], [[2wy1]] – rSer-A8 | **[[2wxz]], [[2wy1]] – rSer-A8 | ||
| - | *Serpin A10 | + | *Serpin A10 or protein Z-dependent protease inhibitor |
| - | **[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z | + | **[[4afx]], [[4aju]] – hSer-A10 (mutant)<br /> |
| + | **[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z<br /> | ||
| + | **[[4ajt]] – mSer-A10 <br /> | ||
*Serpin A12 (Vaspin) | *Serpin A12 (Vaspin) | ||
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**[[4r9i]] – Ser-A18 – bee<br /> | **[[4r9i]] – Ser-A18 – bee<br /> | ||
| - | |||
*Serpin B1 (leukocyte elastase inhibitor) | *Serpin B1 (leukocyte elastase inhibitor) | ||
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*Serpin B4 | *Serpin B4 | ||
| - | **[[ | + | **[[4zk0]] – hSer-B4<br /> |
*Serpin B5 (Maspin) | *Serpin B5 (Maspin) | ||
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*Ser crmA (ice inhibitor) | *Ser crmA (ice inhibitor) | ||
| - | **[[1c8o]], [[1f0c]] – cvSer-crmA (mutant) – cowpox virus<br /> | + | **[[1c8o]], [[1f0c]], [[1m93]] – cvSer-crmA (mutant) – cowpox virus<br /> |
*Serpin E1 see [[Plasminogen activator inhibitor]] | *Serpin E1 see [[Plasminogen activator inhibitor]] | ||
| - | *Serpin E2 | + | *Serpin E2 or Gila-derived nexin |
| - | **[[4dy0]] – hSer-E2 + heparin | + | **[[4dy0]] – hSer-E2 + heparin<br /> |
| + | **[[4dy7]] – hSer-E2 + thrombin<br /> | ||
*Serpin I1 (Neuroserpin) | *Serpin I1 (Neuroserpin) | ||
Revision as of 22:36, 18 September 2018
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3D structures of serpin
Updated on 18-September-2018
References
- ↑ El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic beta Cell Proliferation. Cell Metab. 2016 Jan 12;23(1):194-205. doi: 10.1016/j.cmet.2015.12.001. Epub 2015, Dec 15. PMID:26701651 doi:http://dx.doi.org/10.1016/j.cmet.2015.12.001
- ↑ Quarta S, Vidalino L, Turato C, Ruvoletto M, Calabrese F, Valente M, Cannito S, Fassina G, Parola M, Gatta A, Pontisso P. SERPINB3 induces epithelial-mesenchymal transition. J Pathol. 2010 Jul;221(3):343-56. doi: 10.1002/path.2708. PMID:20527027 doi:http://dx.doi.org/10.1002/path.2708
- ↑ Maass N, Hojo T, Ueding M, Luttges J, Kloppel G, Jonat W, Nagasaki K. Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res. 2001 Apr;7(4):812-7. PMID:11309327
- ↑ Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem. 1997 Mar 21;272(12):7797-800. PMID:9065443
- ↑ Sklate RT, Olcese MC, Maccallini GC, Sarmiento RG, Targovnik HM, Rivolta CM. Novel mutation p.A64D in the Serpina7 gene as a cause of partial thyroxine-binding globulin deficiency associated with increases affinity in transthyretin by a known p.A109T mutation in the TTR gene. Horm Metab Res. 2014 Feb;46(2):100-8. doi: 10.1055/s-0033-1358741. Epub 2013 Dec , 19. PMID:24356794 doi:http://dx.doi.org/10.1055/s-0033-1358741
- ↑ Pontisso P. Role of SERPINB3 in hepatocellular carcinoma. Ann Hepatol. 2014 Nov-Dec;13(6):722-7. PMID:25332258
- ↑ Yang GD, Yang XM, Lu H, Ren Y, Ma MZ, Zhu LY, Wang JH, Song WW, Zhang WM, Zhang R, Zhang ZG. SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. Int J Clin Exp Pathol. 2014 Mar 15;7(4):1348-58. eCollection 2014. PMID:24817931
- ↑ Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A. Allosteric modulation of hormone release from thyroxine and corticosteroid binding-globulins. J Biol Chem. 2011 Feb 16. PMID:21325280 doi:10.1074/jbc.M110.171082
