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	https://www.rcsb.org/pdb/protein/C7Z7K1?addPDB=4WIS		https://www.rcsb.org/pdb/protein/C7Z7K1?addPDB=4WIS

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Revision as of 21:17, 20 February 2018

Contents 1 Structure 2 Function 3 Disease 4 Relevance 5 Structural highlights 6 References

Structure

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Function

Platlet formation/clotting

Phospholipid movement

Apoptosis

Disease

Scott syndrome is a rare human disease caused by a mutation that affects TMEM16 proteins and results in the inability to form platelets correctly.

Relevance

Structural highlights

This protein prefers to form homodimers, which means that the complex is made of two identical chains of itself.

There are multiple sites where calcium ions can bind.

Once Ca ions bind to these sites, the chloride channel can open.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737519/

https://www.rcsb.org/pdb/protein/C7Z7K1?addPDB=4WIS