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Sandbox Reserved 1311

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===Function===
===Function===
Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."<ref>https://www.ncbi.nlm.nih.gov/gene/1401</ref>
Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."<ref>https://www.ncbi.nlm.nih.gov/gene/1401</ref>
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===Structure===
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CRP consists of five identical, noncovalently associated ∼23-kDa protomers arranged symmetrically around a central pore. The term “pentraxins” has been used to describe the family of related proteins with this structure. Each protomer has been found by x-ray crystallography to be folded into two antiparallel β sheets with a flattened jellyroll topology. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. <ref> http://www.jbc.org/content/279/47/48487.full</ref>
==Phosphocholine==
==Phosphocholine==

Revision as of 21:20, 20 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

Caption for this structure

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References

  1. ↑ https://www.ncbi.nlm.nih.gov/gene/1401
  2. ↑ http://www.jbc.org/content/279/47/48487.full
  3. ↑ https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine
  4. ↑ https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine
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