Sandbox Reserved 1334
From Proteopedia
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== Function == | == Function == | ||
| + | 5M05 is a heavy chain myosin protein involved in smooth muscle contractions. It acts as a major contractile protein, using ATP hydrolysis to convert chemical energy to mechanical energy and contract sarcomeres. The protein is homologous to myosin-11 in humans, as both conduct the same function. | ||
== Disease == | == Disease == | ||
| + | Mutations in MYH11, the gene that codes for 5M05, have been identified in individuals with thoracic aortic aneurysms, and the familial version of the condition exhibits genetic and clinical heterogeneity. Additionally, mutations in this gene also appear to contribute to intestinal cancer, but this connection still warrants looking into. | ||
== Structural highlights == | == Structural highlights == | ||
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The <scene name='77/777654/Ligands/2'>ligands</scene> of myosin-11 are responsible for binding to other proteins, crucial for the protein to interact with others as needed in smooth muscle contraction. | The <scene name='77/777654/Ligands/2'>ligands</scene> of myosin-11 are responsible for binding to other proteins, crucial for the protein to interact with others as needed in smooth muscle contraction. | ||
Revision as of 21:20, 20 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Myosin-11 is a smooth-muscle heavy chain used as a contractile protein.
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Contents |
Function
5M05 is a heavy chain myosin protein involved in smooth muscle contractions. It acts as a major contractile protein, using ATP hydrolysis to convert chemical energy to mechanical energy and contract sarcomeres. The protein is homologous to myosin-11 in humans, as both conduct the same function.
Disease
Mutations in MYH11, the gene that codes for 5M05, have been identified in individuals with thoracic aortic aneurysms, and the familial version of the condition exhibits genetic and clinical heterogeneity. Additionally, mutations in this gene also appear to contribute to intestinal cancer, but this connection still warrants looking into.
Structural highlights
The of myosin-11 are responsible for binding to other proteins, crucial for the protein to interact with others as needed in smooth muscle contraction.
The and of myson has an effect on how the protein can bind with actin, which is integral to its role as a contractile protein.
