Sandbox Reserved 1326
From Proteopedia
(Difference between revisions)
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This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10. | + | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1093/emboj/16.17.5162</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. |
== Function == | == Function == | ||
Protein binding:Selectively binds to other protein complexes non-covalently. 1a4y also works to inhibit ANG in order to inhibit angiogenesis, along with RNASE1 to inhibit an endonuclease that cleaves phosphodiester bonds, and RNASE2 . | Protein binding:Selectively binds to other protein complexes non-covalently. 1a4y also works to inhibit ANG in order to inhibit angiogenesis, along with RNASE1 to inhibit an endonuclease that cleaves phosphodiester bonds, and RNASE2 . | ||
== Disease == | == Disease == | ||
| - | Ang has a role in cancers and tumor growth. A mutation in 1a4y which results in decreased activity and thus increased activity of Ang could lead to tumor growth. Ang has also been theorized as a protector of the central nervous system and thus over-production of 1a4y may result in limited Ang and thus neurodegenerative diseases. | + | <scene name='77/777646/Angiogenin/1'>Ang</scene> <scene name='77/777646/Angiogenin/1'>Text To Be Displayed</scene>has a role in cancers and tumor growth. A mutation in 1a4y which results in decreased activity and thus increased activity of Ang could lead to tumor growth. Ang has also been theorized as a protector of the central nervous system and thus over-production of 1a4y may result in limited Ang and thus neurodegenerative diseases. |
== Relevance == | == Relevance == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | <ref>DOI 10.1093/emboj/16.17.5162</ref> | ||
Revision as of 21:49, 20 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Structure of la4y
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References
- ↑ Papageorgiou AC, Shapiro R, Acharya KR. Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. EMBO J. 1997 Sep 1;16(17):5162-77. PMID:9311977 doi:10.1093/emboj/16.17.5162
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
