This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox Reserved 1353
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
==Structure== | ==Structure== | ||
<StructureSection load='1xmi' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1xmi' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| + | Composed of 1480 amino acids in 5 domains, each connected by a nucleotide binding domain. | ||
== Function == | == Function == | ||
The protein regulates transport of bicarbonate and chloride ions. | The protein regulates transport of bicarbonate and chloride ions. | ||
| Line 9: | Line 10: | ||
The protein is crucial for ion circulation in epithelial cells, with lack of function leading to serious disease. | The protein is crucial for ion circulation in epithelial cells, with lack of function leading to serious disease. | ||
== Structural highlights == | == Structural highlights == | ||
| - | The nbd1 domain is altered in CF patients, due to deletion of residue Phe-508 which results in a severe loss of function. | + | The nbd1 domain is altered in CF patients, due to deletion of residue Phe-508 which results in a severe loss of function. |
| + | Mutation at any of the below sites confers resistance to salmonella to the cell. | ||
| + | These mutations also prevent diarrhea from Cholera in mice. | ||
<scene name='77/777673/F508_sites/1'>F508 Mutation Site Nucleotide Binding</scene> | <scene name='77/777673/F508_sites/1'>F508 Mutation Site Nucleotide Binding</scene> | ||
Revision as of 20:59, 21 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
To get started:
More help: Help:Editing |
Structure
| |||||||||||
References
protein
