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6ayc

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Current revision (14:28, 4 October 2023) (edit) (undo)
 
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==Naegleria fowleri CYP51-itraconazole complex==
==Naegleria fowleri CYP51-itraconazole complex==
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<StructureSection load='6ayc' size='340' side='right' caption='[[6ayc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='6ayc' size='340' side='right'caption='[[6ayc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ayc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Amoeba Amoeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ayc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naegleria_fowleri Naegleria fowleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AYC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1YN:2-[(2R)-BUTAN-2-YL]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZIN-1-YL]PHENYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>1YN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tl8|5tl8]], [[6ay4|6ay4]], [[6ay6|6ay6]], [[6ayb|6ayb]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1YN:2-[(2R)-BUTAN-2-YL]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZIN-1-YL]PHENYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>1YN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NF0102700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5762 Amoeba])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ayc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayc OCA], [https://pdbe.org/6ayc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ayc RCSB], [https://www.ebi.ac.uk/pdbsum/6ayc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayc OCA], [http://pdbe.org/6ayc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayc RCSB], [http://www.ebi.ac.uk/pdbsum/6ayc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayc ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A2H4A2U9_NAEFO A0A2H4A2U9_NAEFO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ayc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ayc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Amoeba]]
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[[Category: Large Structures]]
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[[Category: Abagyan, R]]
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[[Category: Naegleria fowleri]]
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[[Category: Aksenov, A]]
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[[Category: Abagyan R]]
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[[Category: Calvet, C M]]
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[[Category: Aksenov A]]
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[[Category: Debnath, A]]
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[[Category: Calvet CM]]
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[[Category: Jennings, G]]
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[[Category: Debnath A]]
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[[Category: Luth, M]]
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[[Category: Jennings G]]
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[[Category: McKerrow, J H]]
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[[Category: Luth M]]
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[[Category: Nes, W D]]
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[[Category: McKerrow JH]]
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[[Category: Podust, L M]]
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[[Category: Nes WD]]
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[[Category: Zhou, W]]
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[[Category: Podust LM]]
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[[Category: Cyp51]]
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[[Category: Zhou W]]
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[[Category: Oxidoreductase]]
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[[Category: Sterol 14alpha-demethylase]]
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Current revision

Naegleria fowleri CYP51-itraconazole complex

PDB ID 6ayc

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