This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6bqh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:48, 4 October 2023) (edit) (undo)
 
Line 1: Line 1:
==Crystal structure of 5-HT2C in complex with ritanserin==
==Crystal structure of 5-HT2C in complex with ritanserin==
-
<StructureSection load='6bqh' size='340' side='right' caption='[[6bqh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='6bqh' size='340' side='right'caption='[[6bqh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6bqh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6bqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQH FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E2J:6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one'>E2J</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HTR2C, HTR1C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E2J:6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one'>E2J</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqh OCA], [http://pdbe.org/6bqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqh RCSB], [http://www.ebi.ac.uk/pdbsum/6bqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqh ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqh OCA], [https://pdbe.org/6bqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bqh RCSB], [https://www.ebi.ac.uk/pdbsum/6bqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/5HT2C_HUMAN 5HT2C_HUMAN]] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.<ref>PMID:12970106</ref> <ref>PMID:18703043</ref> <ref>PMID:19057895</ref> <ref>PMID:7895773</ref>
+
[https://www.uniprot.org/uniprot/5HT2C_HUMAN 5HT2C_HUMAN] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.<ref>PMID:12970106</ref> <ref>PMID:18703043</ref> <ref>PMID:19057895</ref> <ref>PMID:7895773</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 6bqh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6bqh" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus coli migula 1895]]
+
[[Category: Escherichia coli]]
-
[[Category: Bjorn-Yoshimoto, W E]]
+
[[Category: Homo sapiens]]
-
[[Category: Che, T]]
+
[[Category: Large Structures]]
-
[[Category: Cheng, J]]
+
[[Category: Bjorn-Yoshimoto WE]]
-
[[Category: Ding, K]]
+
[[Category: Che T]]
-
[[Category: Gloriam, D E]]
+
[[Category: Cheng J]]
-
[[Category: Han, G W]]
+
[[Category: Ding K]]
-
[[Category: Hanson, M A]]
+
[[Category: Gloriam DE]]
-
[[Category: Harpsoe, K]]
+
[[Category: Han GW]]
-
[[Category: Huang, X P]]
+
[[Category: Hanson MA]]
-
[[Category: Jensen, A A]]
+
[[Category: Harpsoe K]]
-
[[Category: Katritch, V]]
+
[[Category: Huang XP]]
-
[[Category: Lansu, K]]
+
[[Category: Jensen AA]]
-
[[Category: Liu, Z]]
+
[[Category: Katritch V]]
-
[[Category: McCorvy, J D]]
+
[[Category: Lansu K]]
-
[[Category: Nikolajse, L F]]
+
[[Category: Liu Z]]
-
[[Category: Peng, Y]]
+
[[Category: McCorvy JD]]
-
[[Category: Popov, P]]
+
[[Category: Nikolajse LF]]
-
[[Category: Pu, M]]
+
[[Category: Peng Y]]
-
[[Category: Qu, L]]
+
[[Category: Popov P]]
-
[[Category: Roth, B L]]
+
[[Category: Pu M]]
-
[[Category: Shen, L]]
+
[[Category: Qu L]]
-
[[Category: Stevens, R C]]
+
[[Category: Roth BL]]
-
[[Category: Wacker, D]]
+
[[Category: Shen L]]
-
[[Category: Wu, Y]]
+
[[Category: Stevens RC]]
-
[[Category: Yuan, S]]
+
[[Category: Wacker D]]
-
[[Category: Zhao, S]]
+
[[Category: Wu Y]]
-
[[Category: Bril]]
+
[[Category: Yuan S]]
-
[[Category: Gpcr]]
+
[[Category: Zhao S]]
-
[[Category: Human 5-ht2c receptor]]
+
-
[[Category: Lcp]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Ritanserin]]
+
-
[[Category: Selectivity]]
+

Current revision

Crystal structure of 5-HT2C in complex with ritanserin

PDB ID 6bqh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6bqh"
Personal tools