Sandbox Reserved 1380

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Function

Hemoglobin comprises four subunits, each having one polypeptide chain and one heme group. The polypeptide chains of adult hemoglobin themselves are of two kinds, known as alpha and beta chains, similar in length but differing in amino acid sequence. Specially, the image shown is that of the delta chain in the beta chain.

The delta (HBD) and beta (HBB) genes are normally expressed in adultS; in particular, the two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.[4]

Disease

Relevance

Structural highlights

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