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1pn5

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Revision as of 07:32, 9 December 2020

NMR structure of the NALP1 Pyrin domain (PYD)

Structural highlights

1pn5 is a 1 chain structure with sequence from Strsg. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	NALP1 (STRSG)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Signaling in apoptosis and inflammation is often mediated by proteins of the death domain superfamily in the Fas/FADD/Caspase-8 or the Apaf-1/Caspase-9 pathways. This superfamily currently comprises the death domain (DD), death effector domain (DED), caspase recruitment domain (CARD), and pyrin domain (PYD) subfamilies. The PYD subfamily is most abundant, but three-dimensional structures are only available for the subfamilies DD, DED, and CARD, which have an antiparallel arrangement of six alpha helices as common fold. This paper presents the NMR structure of PYD of NALP1, a protein that is involved in the innate immune response and is a component of the inflammasome. The structure of NALP1 PYD differs from all other known death domain superfamily structures in that the third alpha helix is replaced by a flexibly disordered loop. This unique feature appears to relate to the molecular basis of familial Mediterranean fever (FMF), a genetic disease caused by single-point mutations.

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.,Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG, Wuthrich K Structure. 2003 Oct;11(10):1199-205. PMID:14527388^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG, Wuthrich K. NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure. 2003 Oct;11(10):1199-205. PMID:14527388

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pn5"

@@ Line 1: / Line 1: @@
 ==NMR structure of the NALP1 Pyrin domain (PYD)==
-<StructureSection load='1pn5' size='340' side='right' caption='[[1pn5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1pn5' size='340' side='right'caption='[[1pn5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1pn5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1pn5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PN5 FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NALP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn5 OCA], [http://pdbe.org/1pn5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pn5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn5 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn5 OCA], [http://pdbe.org/1pn5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pn5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn5 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 28: / Line 28: @@
 </div>
 <div class="pdbe-citations 1pn5" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Pyrin domain|Pyrin domain]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Strsg]]
 [[Category: Fiorito, F]]

1pn5

From Proteopedia

Revision as of 07:32, 9 December 2020

NMR structure of the NALP1 Pyrin domain (PYD)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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