2evl

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[[Image:2evl.gif|left|200px]]
[[Image:2evl.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2evl |SIZE=350|CAPTION= <scene name='initialview01'>2evl</scene>, resolution 2.200&Aring;
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The line below this paragraph, containing "STRUCTURE_2evl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=LNK:PENTANE'>LNK</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2evl| PDB=2evl | SCENE= }}
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|RELATEDENTRY=[[1sx6|1SX6]], [[2euk|2EUK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evl OCA], [http://www.ebi.ac.uk/pdbsum/2evl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2evl RCSB]</span>
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}}
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'''Crystal structure of human Glycolipid Transfer Protein complexed with 18:2 Galactosylceramide'''
'''Crystal structure of human Glycolipid Transfer Protein complexed with 18:2 Galactosylceramide'''
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[[Category: Malinina, L.]]
[[Category: Malinina, L.]]
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
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[[Category: protein-glycolipid complex]]
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[[Category: Protein-glycolipid complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:09:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:54:21 2008''
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Revision as of 00:09, 4 May 2008

Image:2evl.gif

Template:STRUCTURE 2evl

Crystal structure of human Glycolipid Transfer Protein complexed with 18:2 Galactosylceramide


Overview

Glycosphingolipids (GSLs) play major roles in cellular growth and development. Mammalian glycolipid transfer proteins (GLTPs) are potential regulators of cell processes mediated by GSLs and display a unique architecture among lipid binding/transfer proteins. The GLTP fold represents a novel membrane targeting/interaction domain among peripheral proteins. Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition. Structural comparisons show a highly conserved anchoring of galactosyl- and lactosyl-amide headgroups by the GLTP recognition center. By contrast, acyl chain chemical structure and occupancy of the hydrophobic tunnel dictate partitioning between sphingosine-in and newly-observed sphingosine-out ligand-binding modes. The structural insights, combined with computed interaction propensity distributions, suggest a concerted sequence of events mediated by GLTP conformational changes during GSL transfer to and/or from membranes, as well as during GSL presentation and/or transfer to other proteins.

About this Structure

2EVL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure., Malinina L, Malakhova ML, Kanack AT, Lu M, Abagyan R, Brown RE, Patel DJ, PLoS Biol. 2006 Nov;4(11):e362. PMID:17105344 Page seeded by OCA on Sun May 4 03:09:48 2008

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