This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1qjk

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 08:52, 21 October 2020

Metallothionein MTA from sea urchin (alpha domain)

Structural highlights

1qjk is a 1 chain structure with sequence from Purple sea urchin. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	4mt2, 1qjl
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MTA_STRPU] Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Publication Abstract from PubMed

The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of the sea urchin Strongylocentrotus purpuratus was determined by homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy. MTA is composed of two globular domains, an N-terminal four-metal domain of the amino acid residues 1 to 36 and a Cd4Cys11cluster, and a C-terminal three-metal domain including the amino acid residues 37 to 65 and a Cd3Cys9cluster. The structure resembles the known mammalian and crustacean metallothioneins, but has a significantly different connectivity pattern of the Cys-metal co-ordination bonds and concomitantly contains novel local folds of some polypeptide backbone segments. These differences can be related to variations of the Cys sequence positions and thus emphasize the special role of the cysteine residues in defining the structure of metallothioneins, both on the level of the domain architecture and the topology of the metal-thiolate clusters.

NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA.,Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K. NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA. J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629 doi:10.1006/jmbi.1999.2967

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qjk"

@@ Line 1: / Line 1: @@
 ==Metallothionein MTA from sea urchin (alpha domain)==
-<StructureSection load='1qjk' size='340' side='right' caption='[[1qjk]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1qjk' size='340' side='right'caption='[[1qjk]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1qjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Purple_sea_urchin Purple sea urchin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QJK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1qjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Purple_sea_urchin Purple sea urchin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1QJK FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mt2|4mt2]], [[1qjl|1qjl]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjk OCA], [http://pdbe.org/1qjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qjk RCSB], [http://www.ebi.ac.uk/pdbsum/1qjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qjk ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1qjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjk OCA], [http://pdbe.org/1qjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qjk RCSB], [http://www.ebi.ac.uk/pdbsum/1qjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qjk ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 23: / Line 23: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Purple sea urchin]]
 [[Category: Guntert, P]]

1qjk

From Proteopedia

Revision as of 08:52, 21 October 2020

Metallothionein MTA from sea urchin (alpha domain)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox