Sandbox Reserved 1387
From Proteopedia
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GLUT3 has 481 amino acids, which compose 28 alpha helices. It weighs approximately 52,520 Daltons which is equivalent to 8.72115e-20 grams<ref>https://www.ebi.ac.uk/pdbe/entry/pdb/5c65</ref>. | GLUT3 has 481 amino acids, which compose 28 alpha helices. It weighs approximately 52,520 Daltons which is equivalent to 8.72115e-20 grams<ref>https://www.ebi.ac.uk/pdbe/entry/pdb/5c65</ref>. | ||
- | Its <scene name='77/777707/Hydrophobic_binding_sites/2'>Hydrophobic Binding Sites</scene> are Leucine, Alanine, Phenylalanine, Isoleucine. | + | Its <scene name='77/777707/Hydrophobic_binding_sites/2'>Hydrophobic Binding Sites</scene> are Leucine, Alanine, Phenylalanine, Isoleucine. Its <scene name='77/777707/Hydrophilic_binding_sites/1'>Hydrophilic Binding Sites</scene> are Serine, Glutamic Acid, Arginine, Threonine. The interactions between the hydrophobic and hydrophylic groups allow GLUT3 to bind to octylglucose neopentylglycol and cholesterol hemisuccinate. Both of these substrates have polar and non-polar regions; they are precursors to simpler sugars. |
- | Its <scene name='77/777707/Hydrophilic_binding_sites/1'>Hydrophilic Binding Sites</scene> are Serine, Glutamic Acid, Arginine, Threonine. | + | |
- | <scene name='77/777707/Non_polar_scene/1'>Non Polar Regions</scene> | + | The protein's <scene name='77/777707/Non_polar_scene/1'>Non Polar Regions</scene> are understandably located on the exterior surface, since the complex is embedded in the lipid membrane. |
- | <scene name='77/777707/Polar_regions/1'>Polar Regions</scene> | + | Conversely, GLUT3's <scene name='77/777707/Polar_regions/1'>Polar Regions</scene> are located on the inside of the complex to interact with the substrates. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> |
Revision as of 04:11, 1 March 2018
This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Homo sapien Glucose Transporter GLUT3 / SLC2A3
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References
- ↑ https://www.ebi.ac.uk/pdbe/entry/pdb/5c65
- ↑ Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ. The facilitative glucose transporter GLUT3: 20 years of distinction. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E242-53. doi:, 10.1152/ajpendo.90388.2008. Epub 2008 Jun 24. PMID:18577699 doi:http://dx.doi.org/10.1152/ajpendo.90388.2008
- ↑ doi: https://dx.doi.org/10.2147/CHC.S60484
- ↑ https://www.ebi.ac.uk/pdbe/entry/pdb/5c65