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B-cell lymphoma protein

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[[Image:Bcl-2_3D.jpg|left|200px]]
[[Image:Bcl-2_3D.jpg|left|200px]]
-
'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins. '''Bcl-xL''' (Bcl-2-like protein 1) known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an induced myeloid cell leukemia differentiation protein. '''Bcl-2-L-7''' is called '''Bak''' for Bcl-2 homologous antagonist/killer.
+
'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins. '''Bcl-2''' and '''Bcl-xL''' suppress cell death and '''Bak''' and '''Bax''' promote apoptosis.'''Bcl-xL''' (Bcl-2-like protein 1) known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''. '''Bcl-2-like-7''' is called '''Bak''' for '''Bcl-2 homologous antagonist/killer'''. '''Bcl-2-like-4''' is called '''Bax'''. '''Bcl-2-like-11''' is called '''Bim'''. '''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.
{{Clear}}
{{Clear}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Bcl-xL
+
*Bcl-xL (Bcl-2-like protein 1)
-
**[[1maz]], [[1r2d]], [[2b48]] – hBcl-xL – human<br />
+
**[[1maz]], [[1r2d]], [[2b48]], [[4ppi]] – hBcl-xL – human<br />
**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
-
**[[1lxl]] - hBcl-xL residues 1-209 - NMR<br />
+
**[[2lpc]], [[2m03]], [[2me8]], [[2me9]], [[1lxl]] - hBcl-xL – NMR<br />
-
**[[3pl7]] - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain<br />
+
**[[6bf2]] - hBcl-xL (mutant) – NMR<br />
-
**[[3fdl]] - hBcl-xL + BH3 peptide<br />
+
**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
 +
**[[2mej]] - hBcl-xL + p53 - NMR<br />
**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
-
**[[1ysg]] - hBcl-xL + inhibitor<br />
+
**[[1ysg]], [[3sp7]], [[3spf]], [[3wiz]], [[4tuh]], [[3zln]], [[3zk6]], [[3zlo]], [[3zlr]], [[4c52]], [[4c5d]], [[2yxj]], [[4qnq]], [[4qvx]] - hBcl-xL + inhibitor<br />
-
**[[5fmk]] - hBcl-xL + Bcl-2 BH3 domain<br />
+
**[[2w3l]] – hBcl-xL + quinoline derivative<br />
**[[2w3l]] – hBcl-xL + quinoline derivative<br />
-
**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]] - hBcl-xL + sulfonamide derivative – NMR<br />
+
**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
-
**[[3qkd]] - hBcl-xL + sulfonamide derivative<br />
+
**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
-
**[[2yxj]] - hBcl-xL + antagonist<br />
+
**[[2pon]] - hBcl-xL + Beclin-1- NMR<br />
-
**[[2pon]] - hBcl-xL + Beclin-1<br />
+
**[[2p1l]] - hBcl-xL (mutant) + Beclin-1<br />
**[[2p1l]] - hBcl-xL (mutant) + Beclin-1<br />
-
**[[1g5j]] - hBcl-xL residues 1-209 + BAD peptide (mutant)<br />
 
**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
-
**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant)<br />
+
**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
**[[2bzw]] - mBcl-xL residues 1-211 + BAD<br />
**[[2bzw]] - mBcl-xL residues 1-211 + BAD<br />
-
**[[1pq1]] - mBcl-xL residues 1-196 + Bcl-2-like protein 11<br />
+
**[[1pq1]], [[5c3g]] - mBcl-xL residues 1-196 + BIM peptide<br />
**[[1af3]] - rBcl-xL soluble domain<br />
**[[1af3]] - rBcl-xL soluble domain<br />
-
**[[1bxl]] - Bcl-xL + Bak peptide – ''Escherichia coli'' – NMR<br />
+
**[[1bxl]] - Bcl-xL + Bak peptide – Escherichia coli – NMR<br />
 +
**[[5twa]] - Bcl-xL + Bak peptide – sponge<br />
 +
 
 +
*Bcl-xL complex with BH3 domain peptide
 +
 
 +
**[[3pl7]] - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain<br />
 +
**[[5fmk]], [[5fmj]] - hBcl-xL + Bak BH3 domain<br />
 +
**[[4qve]] - hBcl-xL + BID BH3 domain<br />
 +
**[[1g5j]] - hBcl-xL + BAD BH3 peptide <br />
 +
**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
 +
**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
 +
**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
 +
**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
 +
**[[4a1u]], [[4a1w]] - hBcl-xL + α/β-foldamer BH3 domain<br />
 +
**[[3r85]] - hBcl-xL + heme-binding protein BH3 peptide<br />
 +
**[[2lp8]] – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide - NMR<br />
 +
**[[2m04]] – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR<br />
 +
**[[5wos]] - Bcl-xL + hBIM BH3 domain – canarypox virus<br />
 +
**[[5tzp]] - fpvBcl-xL + BIK BH3 domain – fowlpox virus<br />
 +
**[[5tzq]] - fpvBcl-xL + Bmf BH3 domain <br />
*Bcl-2
*Bcl-2
-
**[[1gjh]], [[1g5m]] – hBcl-2<br />
+
**[[1gjh, [[1g5m]] – hBcl-2<br />
-
**[[4aq3]], [[4man]], [[5jsn]] – hBcl-2 + inhibitor<br />
+
**[[4aq3]], [[4man]], [[5jsn]], [[4ieh]] – hBcl-2 + inhibitor<br />
**[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
**[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
-
**[[5fcg]] – hBcl-2 (mutant) + HBX peptide<br />
+
**[[5fcg]] – hBcl-2 (mutant) + HBX BH3 domain<br />
-
**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator BAX BH3 domain<br />
+
**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain<br />
-
**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative - NMR<br />
+
**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative – NMR
 +
 
 +
*Bcl-2-related protein A1 (Bfl-1)
 +
 
 +
**[[5whi]] - hBcl-2A1 (mutant) <br />
 +
**[[2vm6]] – hBcl-2A1 + hBIM BH3 peptide<br />
 +
**[[2vof]] - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide <br />
 +
**[[2vog]] - mBcl-2A1 + Bmf BH3 peptide <br />
 +
**[[2voh]] - mBcl-2A1 + Bak BH3 peptide <br />
 +
**[[2voi]] - mBcl-2A1 + BID BH3 peptide <br />
 +
**[[3mqp]] - hBcl-2A1 + Noxa BH3 peptide <br />
 +
**[[5uul]] - hBcl-2A1 + PUMA BH3 peptide <br />
 +
**[[5uuk]], [[5uup]] - hBcl-2A1 + Bfl-1 peptide <br />
 +
**[[4zeq]] - hBcl-2A1 + BID BH3 peptide <br />
 +
 
 +
*Bcl-3
 +
 
 +
**[[1k1a]], [[1k1b]] – hBcl-3 ankyrin repeat domain <br />
 +
 
 +
*Bcl-6
 +
 
 +
**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
 +
**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]] – hBcl-6 BTB domain + inhibitor<br />
 +
**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
 +
**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
 +
**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
 +
**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />
 +
**[[2lce]] – hBcl-6 zinc fingers 2-3 - NMR<br />
 +
 
 +
*Bcl-9
 +
 
 +
**[[3sl9]] – hBcl-9 residues 344-396 + catenin beta-1<br />
 +
 
 +
*Bcl-10
 +
 
 +
**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />
 +
**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />
 +
 
 +
*Bcl-W (Bcl-2-like protein 2)
 +
 
 +
**[[1o0l]], [[1mk3]], [[2y6w]] – hBcl-W (mutant) <br />
 +
**[[1zy3]], [[4cim]] - hBcl-W (mutant) + BID BH3 peptide<br />
 +
**[[4k5a]], [[4k5b]] - Bcl-W (mutant) + ankyrin repeat - bovine<br />
 +
**[[4cin]] - hBcl-W + BH3 peptide<br />
 +
 
 +
*Bcl-2-like protein 4 (Bax)
 +
 
 +
**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
 +
**[[4bd8]] – hBax (mutant) <br />
 +
**[[2lr1]] - hBax + VMIA peptide<br />
 +
**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
 +
**[[2k7w]] – hBax + BIM BH3 peptide - NMR<br />
 +
**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />
 +
**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />
 +
 
 +
*Bcl-2-like protein 5
 +
 
 +
**[[3i1h]] - hBcl-2-L-5 + hBak<br />
 +
 
 +
*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
 +
 
 +
**[[2yv6]], 2imt, 2jcn, 2ims – hBak<br />
 +
**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />
 +
**[[4u2v]] – hBak/GFP<br />
 +
**[[3qbr]] - hBak + sjA<br />
 +
**[[2xpx]] - hBak fragment + BHRF1<br />
 +
**[[5vwx]], [[5vwy]], [[5vwz]], [[5vx0]] - hBak + BIM BH3 domain<br />
 +
**[[5vwv]] - hBak (mutant)+ BIM BH3 domain<br />
 +
**[[2m5b]] - hBak + BID BH3 domain - NMR<br />
 +
 
 +
*Bcl-2-like protein 10
 +
 
**[[2kua]] – mBcl-2-L-10<br />
**[[2kua]] – mBcl-2-L-10<br />
-
**[[3io8]] - hBcl-2-L-1 + hBcl-2-L-11 BH3 peptide (mutant)<br />
+
**[[4b4s]] - hBcl-2-L-10 + hBIM BH3 peptide<br />
-
**[[3i1h]] - hBcl-2-L-5 + hBcl-2-L-7<br />
+
-
**[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBcl-2-L-7<br />
+
-
**[[3qbr]] - hBcl-2-L-7 + sjA<br />
+
-
**[[2xpx]] - hBcl-2-L-7 fragment + BHRF1<br />
+
-
**[[2vm6]] – hBcl-2A1 residues 1-149 + hBcl-2-L-11 peptide<br />
+
-
**[[2nl9]] – hBcl-2-L-11 + Mcl-1<br />
+
-
*Bcl-w
+
*Bcl-2-like protein 11 (BIM)
-
**[[1o0l]], [[1mk3]] – hBcl-w (mutant)<br />
+
**[[2nl9]] – hBIM + Mcl-1<br />
-
**[[1zy3]] - hBcl-w (mutant) + BH3 peptide<br />
+
-
*Mcl-1
+
Mcl-1 (Bcl-2-like protein 3)
-
**[[2nla]] – rMcl-1 fragment + NoxaB BH3<br />
+
**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
-
**[[1wsx]] – mMcl-1 residues 152-308<br />
+
-
**[[2jm6]], [[2rod]] – mMcl-1 fragment + NoxaB fragment – NMR<br />
+
-
**[[2roc]] - mMcl-1 fragment + Puma<br />
+
-
**[[3kz0]] - hMcl-1 + peptide MB7<br />
+
**[[3mk8]] - hMcl-1 fragment<br />
**[[3mk8]] - hMcl-1 fragment<br />
**[[2mhs]] - hMcl-1 fragment (mutant)<br />
**[[2mhs]] - hMcl-1 fragment (mutant)<br />
-
**[[3pk1]] – hMcl-1 fragment + hBcl-2-L-4 BH3 domain<br />
 
-
**[[3kj0]], [[3kj1]], [[3kj2]], [[3io9]] - hMcl-1 fragment + hBcl-2-L-11 BH3 domain (mutant)<br />
 
-
**[[3d7v]], [[2pqk]] - hMcl-1 fragment + hBcl-2-L-11 BIM BH3<br />
 
-
**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide – NMR<br />
 
**[[4wms]] - hMcl-1/MBP (mutant) <br />
**[[4wms]] - hMcl-1/MBP (mutant) <br />
**[[5lof]] - hMcl-1/MBP + inhibitor<br />
**[[5lof]] - hMcl-1/MBP + inhibitor<br />
Line 103: Line 175:
**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
-
**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]] - hMcl-1 fragment + inhibitor<br />
+
[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]] - hMcl-1 fragment + inhibitor<br />
-
**[[4bpj]] - hMcl-1 fragment + BH3 peptide <br />
+
**[[5uum]] - hMcl-1 fragment + FS2 peptide <br />
 +
**[[5c3f]] - hMcl-1 fragment + BIB MM <br />
 +
**[[5mes]], [[5mev]] - hMcl-1 fragment + inhibitor + antibody<br />
 +
 
 +
*Mcl-1 complex with BH3 domain peptide
 +
 
 +
**[[2nla]], [[4g35]] – rMcl-1 fragment + NoxaB BH3 domain<br />
 +
**[[2jm6]], [[2rod]] – mMcl-1 fragment + NoxaB fragment – NMR<br />
 +
**[[2roc]] - mMcl-1 fragment + Puma BH3 domain<br />
 +
**[[3kz0]] - hMcl-1 + MB7 BH3 domain<br />
 +
**[[3pk1]] – hMcl-1 fragment + hBax BH3 domain<br />
 +
**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide – NMR<br />
 +
**[[4bpj]], [[4bpi]] - hMcl-1 fragment + Puma BH3 peptide <br />
 +
**[[5c6h]] - hMcl-1 fragment + Mule BH3 peptide <br />
 +
**[[5w89]], [[5w8f]], 3kj0, 3kj1, 3kj2, 3io9, 3d7v, 2pqk, [[5vx2]] - hMcl-1 fragment + BIM BH3 peptide <br />
 +
**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide - NMR <br />
*M11
*M11
**[[2o42]], [[2jbx]] – MvM11L – Myxoma virus<br />
**[[2o42]], [[2jbx]] – MvM11L – Myxoma virus<br />
-
**[[2jby]] – MvM11L + Bcl-2 homologous antagonis <br />
+
**[[2jby]] – MvM11L + Bcl-2 homologous antagonist/killer <br />
-
**[[3dvu]], [[3bl2]] – M11 + Beclin-1 – Murid herpesvirus<br />
+
**[[3dvu]], [[3bl2]], [[4mi8]] – M11 + Beclin-1 – Murid herpesvirus<br />
-
*N1L
+
N1L
**[[2i39]] – VvN1L – Vaccinia virus<br />
**[[2i39]] – VvN1L – Vaccinia virus<br />
**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
-
}}
+
}}
 +
 
==References==
==References==

Revision as of 10:03, 27 February 2018

NMR structure of bcl-2 1g5m

Drag the structure with the mouse to rotate

3D structures of Bcl-2

Updated on 27-February-2018 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Bcl-xL (Bcl-2-like protein 1)
  • Bcl-xL complex with BH3 domain peptide
    • 3pl7 - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain
    • 5fmk, 5fmj - hBcl-xL + Bak BH3 domain
    • 4qve - hBcl-xL + BID BH3 domain
    • 1g5j - hBcl-xL + BAD BH3 peptide
    • 5b1z - hBcl-xL + BHX BH3 domain
    • 4z9v - hBcl-xL + TCTP BH3 domain
    • 2yq6, 4qvf, 4yk9, 3fdl, 5agx, 4yj4, 3io8, 2yq7, 5vx3, 5agw - hBcl-xL + BIM BH3 domain
    • 2yj1, 4bpk, 4hnj - hBcl-xL + α/β-Puma BH3 domain
    • 4a1u, 4a1w - hBcl-xL + α/β-foldamer BH3 domain
    • 3r85 - hBcl-xL + heme-binding protein BH3 peptide
    • 2lp8 – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide - NMR
    • 2m04 – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR
    • 5wos - Bcl-xL + hBIM BH3 domain – canarypox virus
    • 5tzp - fpvBcl-xL + BIK BH3 domain – fowlpox virus
    • 5tzq - fpvBcl-xL + Bmf BH3 domain
  • Bcl-2
    • [[1gjh, 1g5m – hBcl-2
    • 4aq3, 4man, 5jsn, 4ieh – hBcl-2 + inhibitor
    • 4lvt, 4lxd – hBcl-2 (mutant) + inhibitor
    • 5fcg – hBcl-2 (mutant) + HBX BH3 domain
    • 2xa0 – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain
    • 2o21, 2o22, 2o2f, 1ysw - hBcl-2 + sulfonamide derivative – NMR
  • Bcl-2-related protein A1 (Bfl-1)
    • 5whi - hBcl-2A1 (mutant)
    • 2vm6 – hBcl-2A1 + hBIM BH3 peptide
    • 2vof - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide
    • 2vog - mBcl-2A1 + Bmf BH3 peptide
    • 2voh - mBcl-2A1 + Bak BH3 peptide
    • 2voi - mBcl-2A1 + BID BH3 peptide
    • 3mqp - hBcl-2A1 + Noxa BH3 peptide
    • 5uul - hBcl-2A1 + PUMA BH3 peptide
    • 5uuk, 5uup - hBcl-2A1 + Bfl-1 peptide
    • 4zeq - hBcl-2A1 + BID BH3 peptide
  • Bcl-3
    • 1k1a, 1k1b – hBcl-3 ankyrin repeat domain
  • Bcl-6
  • Bcl-9
    • 3sl9 – hBcl-9 residues 344-396 + catenin beta-1
  • Bcl-10
    • 2mb9 – hBcl-10 CARD domain (mutant) – NMR
    • 6bze – hBcl-10 CARD domain – Cryo EM
  • Bcl-W (Bcl-2-like protein 2)
    • 1o0l, 1mk3, 2y6w – hBcl-W (mutant)
    • 1zy3, 4cim - hBcl-W (mutant) + BID BH3 peptide
    • 4k5a, 4k5b - Bcl-W (mutant) + ankyrin repeat - bovine
    • 4cin - hBcl-W + BH3 peptide
  • Bcl-2-like protein 4 (Bax)
  • Bcl-2-like protein 5
    • 3i1h - hBcl-2-L-5 + hBak
  • Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
  • Bcl-2-like protein 10
    • 2kua – mBcl-2-L-10
    • 4b4s - hBcl-2-L-10 + hBIM BH3 peptide
  • Bcl-2-like protein 11 (BIM)
    • 2nl9 – hBIM + Mcl-1

Mcl-1 (Bcl-2-like protein 3)

    • 1wsx – mMcl-1 residues 152-308 - NMR
    • 3mk8 - hMcl-1 fragment
    • 2mhs - hMcl-1 fragment (mutant)
    • 4wms - hMcl-1/MBP (mutant)
    • 5lof - hMcl-1/MBP + inhibitor
    • 4wmx, 4wmw, 4wmv - hMcl-1/MBP + ligand
    • 4wmu, 4wmt - hMcl-1/MBP (mutant) + ligand
    • 4wgi - hMcl-1/MBP (mutant) + macrolactam

3wix, 3wiy, 4oq5, 4oq6, 4hw2, 4hw3, 4hw4, 4wmr, 4zbf, 4zbi, 5fc4, 5fdo, 5fdr, 5iez, 5if4, 5jsb, 5ku9, 5vkc, 6b4l, 6b4u, 6bw2, 6bw8 - hMcl-1 fragment + inhibitor

    • 5uum - hMcl-1 fragment + FS2 peptide
    • 5c3f - hMcl-1 fragment + BIB MM
    • 5mes, 5mev - hMcl-1 fragment + inhibitor + antibody
  • Mcl-1 complex with BH3 domain peptide
    • 2nla, 4g35 – rMcl-1 fragment + NoxaB BH3 domain
    • 2jm6, 2rod – mMcl-1 fragment + NoxaB fragment – NMR
    • 2roc - mMcl-1 fragment + Puma BH3 domain
    • 3kz0 - hMcl-1 + MB7 BH3 domain
    • 3pk1 – hMcl-1 fragment + hBax BH3 domain
    • 2kbw - hMcl-1 fragment + BID BH3 peptide – NMR
    • 4bpj, 4bpi - hMcl-1 fragment + Puma BH3 peptide
    • 5c6h - hMcl-1 fragment + Mule BH3 peptide
    • 5w89, 5w8f, 3kj0, 3kj1, 3kj2, 3io9, 3d7v, 2pqk, 5vx2 - hMcl-1 fragment + BIM BH3 peptide
    • 2kbw - hMcl-1 fragment + BID BH3 peptide - NMR
  • M11
    • 2o42, 2jbx – MvM11L – Myxoma virus
    • 2jby – MvM11L + Bcl-2 homologous antagonist/killer
    • 3dvu, 3bl2, 4mi8 – M11 + Beclin-1 – Murid herpesvirus

N1L

}}

References

1. Mee Young Hong; Chapkin, Robert S.; Davidson, Laurie A.; Turner, Nancy D.; Morris, Jeffrey S.; Carroll, Raymond J.; Lupton, Joanne R.. Nutrition & Cancer, 2003, Vol. 46 Issue 1, p44-44, 8p; DOI: NO_DOI; (AN 10719727)

2. Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG, Advances In Experimental Medicine And Biology, ISSN: 0065-2598, 1996; Vol. 406, pp. 99-112; PMID: 8910675

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